Recombinant Human RISC protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The RISC complex takes part in regulating gene expression by degrading target mRNAs or inhibiting their translation once bound to them. It is part of the RNA interference (RNAi) machinery a mechanism important for maintaining cellular homeostasis through gene expression control. The effector part of RISC recognizes and binds to complementary sequences on target mRNAs harnessing its RNA-binding capabilities to mediate gene silencing effectively. This process helps to regulate developmental timings cellular responses to stress and defense against viral infections.

Pathways

The RISC complex integrates into pathways like RNA interference and miRNA-mediated gene silencing important for controlling gene expression at the post-transcriptional level. Within these pathways RISC interacts with proteins such as Dicer which processes precursor RNA molecules into mature siRNA or miRNA that RISC then utilizes for gene silencing. By interacting with these proteins RISC facilitates an intricate network of genetic regulation essential for cellular integrity and function.