Recombinant Human RNA polymerase II RPB11 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RNA polymerase II RPB11 also known as hRPB11 is a core subunit of the RNA polymerase II complex with a molecular weight of approximately 15 kDa. As part of this multi-subunit enzyme RPB11 plays an integral role in the transcription of DNA into mRNA a necessary step for gene expression. It is expressed across various tissues reflecting its fundamental role in cellular function. RPB11 facilitates the assembly of the RNA polymerase II complex contributing to the enzyme's structural stability and interaction capacity with other subunits.

Biological function summary

RPB11 is a component of the larger RNA polymerase II complex which includes several other protein subunits. It plays a significant role in the synthesis of pre-mRNA which eventually gets processed into mature mRNA. This translation process is essential for the protein production from genes. RPB11’s involvement in transcription indicates its participation in regulating gene expression which is an important mechanism for cellular response and adaptation to internal and environmental signals. It collaborates with other core subunits like RPB1 and RPB2 to ensure effective transcription initiation elongation and termination.

Pathways

RNA polymerase II operates centrally in the transcriptional regulation pathway and is essential in the cell cycle control pathway. As a core subunit RPB11 supports the functions of RNA polymerase II in these pathways facilitating the transcription of genes responsible for cell cycle progression and growth. It closely associates with other cellular proteins such as transcription factors that guide and enhance the polymerase's functions. Additionally it links with cofactors and transcriptional machinery to modulate gene expression integrating signals from various signaling pathways to exert control over the genome expression.

RPB11's function connects to transcriptional dysregulation seen in various cancers. Abnormalities in RNA polymerase II subunits including RPB11 can lead to improper gene expression contributing to oncogenesis. Furthermore disruptions in its roles have ties to neurodegenerative disorders where faulty protein synthesis may occur due to impaired transcriptional operations. Proteins such as p53 a tumor suppressor also interact with RPB11 in the context of these diseases where they co-regulate transcriptional activities necessary for DNA damage response and cell cycle regulation.