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AB159359

Recombinant Human RNASE6 protein (GST tag N-Terminus)

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Recombinant Human RNASE6 protein (GST tag N-Terminus) is a Human Full Length protein, in the 24 to 150 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

RNS6, RNASE6, Ribonuclease K6, RNase K6

1 Images
SDS-PAGE - Recombinant Human RNASE6 protein (GST tag N-Terminus) (AB159359)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RNASE6 protein (GST tag N-Terminus) (AB159359)

ab159359 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q93091

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"WPKRLTKAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFLHDSFQNVAAVCDLLSIVCKNRRHNCHQSSKPVNMTDCRLTSGKYPQCRYSAAAQYKFFIVACDPPQKSDPPYKLVPVHLDSIL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":150,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q93091","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RNASE6 also called ribonuclease K6 is a member of the ribonuclease A superfamily. It has a molecular mass around 16 kDa. This protein shows ribonuclease activity meaning it can degrade RNA molecules. RNASE6 is expressed in several tissues and cells including leukocytes. Its enzymatic action contributes to the defense system by degrading foreign RNA and may influence inflammatory responses.
Biological function summary

Ribonuclease K6 plays a part in the immune response. It acts as a single entity rather than as part of a complex. This protein helps to defend the body against pathogens by breaking down their RNA reducing their ability to multiply and spread. Beyond its antiviral action RNASE6 can modulate immune cell functions making it a potential component in controlling inflammation and autoimmunity.

Pathways

Several immune-associated cascades involve ribonuclease K6. Specifically RNASE6 intersects with the pathways responsible for pathogen recognition and immune cell activation. These pathways involve proteins such as toll-like receptors (TLRs) which detect microbial components and cytokines which coordinate immune responses. RNASE6 helps in the breakdown of RNA from invading pathogens in these pathways supporting the overall defense mechanism.

Possible links exist between ribonuclease K6 and conditions like infections and inflammatory diseases. In antimicrobial defense RNASE6 may affect the body's susceptibility to bacterial infections. Moreover its role in the immune system suggests potential involvement in autoimmune disorders where the body's immune system mistakenly attacks its own tissues. Studies hint at an interplay between RNASE6 and cytokines which are key players in both fighting infections and driving autoimmune responses.
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Specifications

Form

Liquid

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General info

Function

Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed : 27013146, PubMed : 8836175). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed : 25075772, PubMed : 27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed : 27089320). Probably contributes to urinary tract sterility (PubMed : 25075772). Bactericidal activity is independent of RNase activity (PubMed : 27089320).

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Subcellular localisation

Lysosome

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Product protocols

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Target data

Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed : 27013146, PubMed : 8836175). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed : 25075772, PubMed : 27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed : 27089320). Probably contributes to urinary tract sterility (PubMed : 25075772). Bactericidal activity is independent of RNase activity (PubMed : 27089320).
See full target information RNASE6
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Product promise

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