Recombinant Human RND1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RND1 also known as Rho6 is a small 29 kDa GTP-binding protein within the Rho family. It functions as a GTPase which means it binds and hydrolyzes GTP. RND1 lacks GTPase activity therefore it remains in a constitutively active GTP-bound state. This protein is expressed in various tissues but shows higher levels in the brain and heart. Its activity influences cytoskeletal dynamics which impacts cellular shape and movement.

Biological function summary

RND1 plays a significant role in cytoskeletal organization and neuronal development. Through its interactions with specific downstream effectors RND1 regulates actin filament assembly which affects cell adhesion and migration. Although not typically a component of larger protein complexes RND1's influence on actin dynamics positions it at an important nodal point in controlling cell shape and motility.

Pathways

RND1 fits into signaling pathways that control actin cytoskeleton reorganization. One notable pathway is the Rho signaling pathway where RND1 interacts with other members of the Rho family like RhoA. RND1's effects on actin dynamics also connect it to the cadherin-mediated cell-cell junction pathway. Through these pathways RND1's activity moderates interactions between cells and the extracellular matrix influencing cellular morphology and adhesion properties.

RND1 has been implicated in certain cancers and cardiovascular diseases. In cancer dysregulation of RND1 alters cell migration and invasion contributing to tumor progression and metastasis. It also associates with proteins involved in cell migration such as Rac1 and Cdc42. In cardiovascular conditions abnormal regulation of RND1 can affect vascular remodeling and cardiac hypertrophy. Here its relationship with signaling proteins like ROCK1 becomes relevant affecting cellular processes at the heart tissue level.