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AB97952

Recombinant Human RND3 protein

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(1 Publication)

Recombinant Human RND3 protein is a Human Full Length protein, in the 1 to 241 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ARHE, RHO8, RHOE, RND3, Rho-related GTP-binding protein RhoE, Protein MemB, Rho family GTPase 3, Rho-related GTP-binding protein Rho8, Rnd3

1 Images
SDS-PAGE - Recombinant Human RND3 protein (AB97952)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human RND3 protein (AB97952)

15% SDS-PAGE showing ab97952 at approximately 29.2kDa (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P61587

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 40% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRISHMPSRPELSAVATDLRKDKAKSC","proteinLength":"Full Length","predictedMolecularWeight":"29.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":241,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P61587","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RND3 also known as RhoE is a small GTPase with a molecular mass of approximately 25 kDa. It belongs to the Rho family of GTPases. RND3 lacks intrinsic GTPase activity which makes it constantly bound to GTP. This protein gets expressed in several tissues including the brain heart and skeletal muscles. By interfering with the actin cytoskeleton RND3 regulates cell shape and movement.
Biological function summary

The functions of RND3 involve the regulation of the cytoskeleton contributing to processes such as cell adhesion and migration. RND3 operates independently not forming part of a larger protein complex yet it plays a pivotal role in modulating the activity of other signaling molecules. Its influence on the cytoskeleton makes it an important player in maintaining cellular architecture and dynamics which is fundamental for tissue integrity and repair.

Pathways

RND3 is intricately involved in the MAPK and PI3K/AKT signaling pathways. These pathways are essential for cell growth migration and survival. RND3 interacts with proteins such as ROCK1 and ROCK2 in these pathways affecting downstream activities positively or negatively. The regulation of these signaling cascades by RND3 shows its importance in cellular responses to environmental cues.

RND3 is linked to cancer and cardiovascular diseases. Alterations in RND3 expression or function can contribute to the uncontrolled cell proliferation seen in various cancers. In cancer its interactions with signaling proteins like AKT lead to enhanced survival signaling. In the context of cardiovascular diseases RND3 influences vascular smooth muscle cell behavior impacting atherosclerosis progression. Through these connections RND3 emerges as a significant target for therapeutic research.
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Specifications

Form

Liquid

Additional notes

ab97952 is purified using conventional chromatography techniques.

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General info

Function

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

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Product protocols

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Target data

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
See full target information RND3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell science 133: PubMed32041905

2020

Rnd3 interacts with TAO kinases and contributes to mitotic cell rounding and spindle positioning.

Applications

Unspecified application

Species

Unspecified reactive species

Ritu Garg,Chuay-Yeng Koo,Elvira Infante,Caterina Giacomini,Anne J Ridley,Jonathan D H Morris
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