JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276243

Recombinant Human Robo2 protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human Robo2 protein (His tag) is a Human Fragment protein, in the 1 to 859 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

KIAA1568, ROBO2, Roundabout homolog 2

1 Images
SDS-PAGE - Recombinant Human Robo2 protein (His tag) (AB276243)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Robo2 protein (His tag) (AB276243)

SDS-PAGE analysis of ab276243

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9HCK4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

style
left-column

Complementary Products

Primary Antibodies

AB314580

Anti-Robo2 antibody [EPR27948-76] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-Robo2 antibody [EPR27948-76] - BSA and Azide free (Detector) (AB314580)

  • 0
  • 0
Assay Kits

AB314578

Robo2 Antibody Pair - BSA and Azide free

RabMAb

Sandwich ELISA - Robo2 Antibody Pair - BSA and Azide free (AB314578)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQP","proteinLength":"Fragment","predictedMolecularWeight":"94.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":859,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9HCK4","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Robo2 also known as Roundabout Homolog 2 is a protein with significant roles in axon guidance. This protein has a molecular mass of approximately 147 kDa and is a member of the Robo receptor family. It is primarily expressed in the nervous system including areas such as the spinal cord brain and olfactory bulb. Robo2 interacts with Slit proteins to mediate the repulsive guidance of axons which is fundamental for the formation of connections in the developing nervous system.
Biological function summary

Robo2 functions in the nervous system to guide axons and establish neuron networks. It plays a role in cellular processes like migration and axonal pathfinding ensuring proper connectivity. Robo2 operates as a receptor and does not form part of a larger complex by itself but it does have interactions with other molecules. By binding with Slit proteins Robo2 helps repel axons away from certain areas aiding in the clear mapping of axonal trajectories.

Pathways

Robo2 participates in axon guidance pathways including the Slit-Robo signaling pathway. This pathway is fundamental in nervous system development and is responsible for steering axonal growth direction. Within these pathways Robo2 displays interaction with proteins like neuron-specific Slit proteins which are secreted molecules helping to establish gradients that direct axon shrinkage or extension.

Robo2 is linked to conditions like congenital heart defects and urofacial syndrome. Abnormal expression or mutations in the Robo2 gene may disrupt normal axonal pathfinding leading to developmental issues. Robo2 has also shown associations with other proteins like Slit2 which together contribute to defective axon guidance when altered underlying certain neurodevelopmental disorders.
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.

Sequence similarities

Belongs to the immunoglobulin superfamily. ROBO family.

style
left-column

Product protocols

style
left-column

Target data

Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
See full target information ROBO2
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com