Recombinant Human ROR1 protein is a Human Fragment protein, in the 30 to 406 aa range, expressed in CHO, with >95% purity and suitable for SDS-PAGE, HPLC.
Q E T E L S V S A E L V P T S S W N I S S E L N K D S Y L T L D E P M N N I T T S L G Q T A E L H C K V S G N P P P T I R W F K N D A P V V Q E P R R L S F R S T I Y G S R L R I R N L D T T D T G Y F Q C V A T N G K E V V S S T G V L F V K F G P P P T A S P G Y S D E Y E E D G F C Q P Y R G I A C A R F I G N R T V Y M E S L H M Q G E I E N Q I T A A F T M I G T S S H L S D K C S Q F A I P S L C H Y A F P Y C D E T S S V P K P R D L C R D E C E I L E N V L C Q T E Y I F A R S N P M I L M R L K L P N C E D L P Q P E S P E A A N C I R I G I P M A D P I N K N H K C Y N S T G V D Y R G T V S V T K S G R Q C Q P W N S Q Y P H T H T F T A L R F P E L N G G H S Y C R N P G N Q K E A P W C F T L D E N F K S D L C D I P A C D S K D S K E K N K M E I L Y
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
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Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068).
NTRKR1, ROR1, Inactive tyrosine-protein kinase transmembrane receptor ROR1
Recombinant Human ROR1 protein is a Human Fragment protein, in the 30 to 406 aa range, expressed in CHO, with >95% purity and suitable for SDS-PAGE, HPLC.
Constituents: 0.16% Sodium phosphate
>95 % by HPLC analysis.
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068).
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
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