Recombinant human ROR1 protein (Tagged) is a Human Fragment protein, in the 540 to 795 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
>95% SDS-PAGE
< 1 EU/µg
Escherichia coli
His tag N-Terminus
T7 tag N-Terminus
SDS-PAGE
Yes
M G S S H H H H H H S S G L V P R G S H M A S M T G G Q Q M G R G S E F - G A V T Q E Q P V C M L F E Y I N Q G D L H E F L I M R S P H S D V G C S S D E D G T V K S S L D H G D F L H I A I Q I A A G M E Y L S S H F F V H K D L A A R N I L I G E Q L H V K I S D L G L S R E I Y S A D Y Y R V Q S K S L L P I R W M P P E A I M Y G K F S S D S D I W S F G V V L W E I F S F G L Q P Y Y G F S N Q E V I E M V R K R Q L L P C S E D C P P R M Y S L M T E C W N E I P S R R P R F K D I H V R L R S W E G L S S H T S S T T P S G G N A T T Q T T S L S A S P V S N L S N P R Y P N Y M F P S Q G
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068).
NTRKR1, ROR1, Inactive tyrosine-protein kinase transmembrane receptor ROR1
Recombinant human ROR1 protein (Tagged) is a Human Fragment protein, in the 540 to 795 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
>95% SDS-PAGE
< 1 EU/µg
Escherichia coli
His tag N-Terminus
T7 tag N-Terminus
SDS-PAGE
Yes
Active
No
Human
In sterile PBS. pH 7.2 - 7.4
Constituents: 82.8% Trehalose, 16.38% PBS, 0.17% Sodium-N-Lauroylsarcosinate
M G S S H H H H H H S S G L V P R G S H M A S M T G G Q Q M G R G S E F - G A V T Q E Q P V C M L F E Y I N Q G D L H E F L I M R S P H S D V G C S S D E D G T V K S S L D H G D F L H I A I Q I A A G M E Y L S S H F F V H K D L A A R N I L I G E Q L H V K I S D L G L S R E I Y S A D Y Y R V Q S K S L L P I R W M P P E A I M Y G K F S S D S D I W S F G V V L W E I F S F G L Q P Y Y G F S N Q E V I E M V R K R Q L L P C S E D C P P R M Y S L M T E C W N E I P S R R P R F K D I H V R L R S W E G L S S H T S S T T P S G G N A T T Q T T S L S A S P V S N L S N P R Y P N Y M F P S Q G
Fragment
104 kDa
32.8 kDa
540 to 795
Recombinant
His tag N-Terminus, T7 tag N-Terminus
Lyophilized
nan
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068).
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Blue Ice
1-2 weeks
+4°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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Terms & Conditions.
Recombinant human ROR1 protein fragment (ab270600) resolved on a 15% SDS-PAGE gel.
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