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Recombinant human ROR1 protein (Tagged) is a Human Fragment protein, in the 540 to 795 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant human ROR1 protein (Tagged) (AB270600), expandable thumbnail

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag N-Terminus
T7 tag N-Terminus

Applications

SDS-PAGE

Biologically active

Yes

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M A S M T G G Q Q M G R G S E F - G A V T Q E Q P V C M L F E Y I N Q G D L H E F L I M R S P H S D V G C S S D E D G T V K S S L D H G D F L H I A I Q I A A G M E Y L S S H F F V H K D L A A R N I L I G E Q L H V K I S D L G L S R E I Y S A D Y Y R V Q S K S L L P I R W M P P E A I M Y G K F S S D S D I W S F G V V L W E I F S F G L Q P Y Y G F S N Q E V I E M V R K R Q L L P C S E D C P P R M Y S L M T E C W N E I P S R R P R F K D I H V R L R S W E G L S S H T S S T T P S G G N A T T Q T T S L S A S P V S N L S N P R Y P N Y M F P S Q G

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068).

Alternative names

Recommended products

Recombinant human ROR1 protein (Tagged) is a Human Fragment protein, in the 540 to 795 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Applications

SDS-PAGE

Biological activity

Active

Accession
Q01973-1
Animal free

No

Species

Human

Reconstitution

In sterile PBS. pH 7.2 - 7.4

Concentration
Loading...
Storage buffer

Constituents: 82.8% Trehalose, 16.38% PBS, 0.17% Sodium-N-Lauroylsarcosinate

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M A S M T G G Q Q M G R G S E F - G A V T Q E Q P V C M L F E Y I N Q G D L H E F L I M R S P H S D V G C S S D E D G T V K S S L D H G D F L H I A I Q I A A G M E Y L S S H F F V H K D L A A R N I L I G E Q L H V K I S D L G L S R E I Y S A D Y Y R V Q S K S L L P I R W M P P E A I M Y G K F S S D S D I W S F G V V L W E I F S F G L Q P Y Y G F S N Q E V I E M V R K R Q L L P C S E D C P P R M Y S L M T E C W N E I P S R R P R F K D I H V R L R S W E G L S S H T S S T T P S G G N A T T Q T T S L S A S P V S N L S N P R Y P N Y M F P S Q G

Accession

Q01973

Protein length

Fragment

Predicted molecular weight

104 kDa

Amino acids

540 to 795

Nature

Recombinant

Tags

His tag N-Terminus, T7 tag N-Terminus

Specifications

Form

Lyophilized

Additional notes

nan

General info

Function

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068).

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • SDS-PAGE - Recombinant human ROR1 protein (Tagged) (ab270600), expandable thumbnail

    SDS-PAGE - Recombinant human ROR1 protein (Tagged) (ab270600)

    Recombinant human ROR1 protein fragment (ab270600) resolved on a 15% SDS-PAGE gel.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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