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AB167904

Recombinant Human RPL26 protein

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Recombinant Human RPL26 protein is a Human Full Length protein, in the 1 to 145 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Large ribosomal subunit protein uL24, 60S ribosomal protein L26, RPL26

1 Images
SDS-PAGE - Recombinant Human RPL26 protein (AB167904)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human RPL26 protein (AB167904)

15% SDS-PAGE analysis of ab167904 (3µg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P61254

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 40% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Ribosomal protein L26
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEETIEKMQE","proteinLength":"Full Length","predictedMolecularWeight":"19.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":145,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P61254","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPL26 also known as Ribosomal Protein L26 is a component of the 60S subunit of the ribosome. It has a mass of approximately 17 kDa. This protein primarily expresses in tissues with high levels of protein synthesis including muscle liver and brain. As part of the ribosome RPL26 plays an essential role in the synthesis of proteins by facilitating the assembly of amino acids into polypeptide chains.
Biological function summary

RPL26 contributes to the complex process of translation by ensuring the stability and proper function of the ribosome. As a structural part of the large ribosomal subunit it helps maintain the integrity of the ribosomal architecture necessary for effective translation. This protein also indirectly affects mRNA processing and mRNA stability both of which influence the efficiency of protein synthesis.

Pathways

RPL26 participates in translation and ribosome biogenesis pathways. It interacts closely with other ribosomal proteins and rRNA to form the functional ribosome. Within these pathways RPL26 is linked with proteins like RPL5 and RPL11 which also contribute to the assembly and stability of the ribosome. Efficient protein synthesis by this pathway is fundamental for cellular growth and proliferation.

RPL26 is associated with conditions like Diamond-Blackfan anemia and cancer. Diamond-Blackfan anemia is a ribosomopathy resulting from mutations in ribosomal proteins including RPL26 disrupting normal erythropoiesis. The depletion or malfunction of RPL26 can also influence cancer progression by altering the translational capacity of cancer cells affecting proteins like p53 that control cell cycle and apoptosis.
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Specifications

Form

Liquid

Additional notes

ab167904 is purified using conventional chromatography techniques.

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General info

Function

Component of the large ribosomal subunit (PubMed : 23636399, PubMed : 26100019, PubMed : 32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 23636399, PubMed : 26100019, PubMed : 32669547).

Sequence similarities

Belongs to the universal ribosomal protein uL24 family.

Post-translational modifications

Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

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Product protocols

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Target data

Component of the large ribosomal subunit (PubMed : 23636399, PubMed : 26100019, PubMed : 32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 23636399, PubMed : 26100019, PubMed : 32669547).
See full target information RPL26
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Complementary Products

Primary Antibodies

AB157111

Anti-RPL26 antibody

Western blot - Anti-RPL26 antibody (AB157111)

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Primary Antibodies

AB59567

Anti-RPL26 + RPL26L1 antibody

Western blot - Anti-RPL26 + RPL26L1 antibody (AB59567)

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Primary Antibodies

AB109305

Anti-UFM1 antibody [EPR4264(2)]

KO Validated|RabMAb|Recombinant

Western blot - Anti-UFM1 antibody [EPR4264(2)] (AB109305)

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  • 4
Proteins & Peptides

AB269005

Recombinant Human Tau (mutated L266V) protein

SDS-PAGE - Recombinant Human Tau (mutated L266V) protein (AB269005)

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