Recombinant Human RPL27A protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPL27A also known as ribosomal protein L27a is a component of the 60S large ribosomal subunit. It has a molecular weight of approximately 17 kDa and is highly conserved across species. RPL27A plays an important role in protein synthesis by facilitating the assembly of ribosomes. The protein exhibits widespread expression in various tissues reflecting its essential function in maintaining cellular processes.

Biological function summary

The function of RPL27A is to support the structural stability of ribosomes. It contributes to the formation of the ribosomal complex which is pivotal for translation. This protein interacts closely with other ribosomal proteins and ribosomal RNA to ensure accurate mRNA decoding and peptide bond formation. The integrity of the ribosomal complex is dependent on RPL27A highlighting its importance in cellular growth.

Pathways

The involvement of RPL27A in the ribosome biogenesis and protein synthesis pathways is significant. It plays a role in orchestrating the translation process where it works alongside proteins like RPL10 and RPL5. These pathways are essential for normal cell proliferation and function supporting various cellular activities and responses.

RPL27A has associations with disorders such as Diamond-Blackfan anemia and certain cancers. Mutations or dysregulation in RPL27A can impair ribosome function leading to anemia due to bone marrow failure and can contribute to tumorigenesis by affecting cell growth. In Diamond-Blackfan anemia RPL27A interacts with other defective ribosomal proteins hinting at a potential pathway disruption that leads to the disease.