Recombinant Human RPL34 protein (denatured)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The RPL34 protein also known as ribosomal protein L34 is integral to the function of ribosomes where it plays a role in protein synthesis. It is a component of the 60S large ribosomal subunit and has a molecular mass of approximately 13 kDa. RPL34 is expressed in a wide range of tissues reflecting its essential role in the general process of translation. The conservation of RPL34 across species highlights its fundamental function in cellular machinery.

Biological function summary

RPL34 participates in the assembly and function of the ribosomal complex essential for translating mRNA into proteins. As part of the ribosome it interacts with rRNA and other ribosomal proteins to form a functional unit necessary for protein synthesis. The activity of RPL34 ensures accurate translation and effective cellular protein production reinforcing the ribosome's role as the cell's protein factory. Disruptions in its function can lead to impaired cellular processes due to defective protein production.

Pathways

RPL34 plays a vital role in the translation pathway where it ensures the correct assembly and function of the ribosomal complex. It is part of the ribosome biogenesis pathway which involves numerous other ribosomal proteins and factors. Its interaction with other ribosomal proteins such as RPL5 and RPL11 ensures efficient ribosomal assembly and function which is important for cellular homeostasis. The proper function of these pathways is important for maintaining cellular growth and division.

Mutations or dysregulation in RPL34 can be linked to ribosomopathies which include Diamond-Blackfan anemia a disorder characterized by anemia and congenital abnormalities. Research also suggests a connection between RPL34 and cancer where altered expression levels can contribute to tumorigenesis via the deregulation of ribosome biogenesis. The link with proteins like MDM2 involved in ribosome activity and cell cycle regulation further implicates RPL34 in pathways that could lead to disease when aberrantly expressed or mutated.