Recombinant Human RPL35A protein (denatured) (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPL35A also known as 60S ribosomal protein L35a is a component of the ribosome particularly within the large 60S subunit. This protein has a mass of approximately 16.6 kDa and is expressed ubiquitously across various tissues consistent with its role in protein synthesis. The widespread expression indicates its importance in maintaining normal cell functions due to its involvement in ribosomal function.

Biological function summary

Researchers recognize RPL35A as a part of the ribosome complex which is essential for translation during protein synthesis. This complex participates directly in the assembly of polypeptide chains from mRNA transcripts. By engaging in this fundamental process RPL35A ensures that proteins are synthesized accurately and efficiently contributing to cellular homeostasis and growth.

Pathways

Researchers note that RPL35A plays a part in the mRNA translation pathway and the ribosome biogenesis pathway. Its function in assembling ribosomal subunits connects it to proteins like RPL11 and RPS19 which are also important components of the ribosome. These interconnected pathways facilitate the synthesis of proteins impacting cellular activities and overall organism development.

Scientists link RPL35A function to Diamond-Blackfan Anemia a rare genetic disorder that affects red blood cell production. In this condition mutations or deficiencies in RPL35A disrupt normal ribosome function leading to insufficient erythropoiesis. Additionally RPL35A interacts with other ribosomal proteins such as RPS19 another gene associated with Diamond-Blackfan Anemia emphasizing the complexity of ribosomal malfunctions in disease pathogenesis.