Recombinant Human RPN2 protein (His tag)
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Recombinant Human RPN2 protein (His tag) is a Human Fragment protein, in the 1 to 540 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit, RIBIIR, Ribophorin II, Ribophorin-2, RPN-II, RPN2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human RPN2 protein (His tag) (AB276632)
SDS-PAGE analysis of ab276632
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RPN2 is integral to the OST complex which consists of multiple subunits each contributing to the glycosylation process. By enabling glycosylation RPN2 ensures proper protein folding allowing proteins to achieve functional conformation and maintain stability. This process affects various cellular activities including protein secretion cell surface receptor expression and immune function.
Pathways
RPN2 plays a significant role in the N-linked glycosylation pathway. This pathway involves the attachment of glycans to proteins influencing their folding distribution and function. RPN2 interacts with other proteins such as STT3A and STT3B which are essential components of the OST complex. This interaction modulates protein modification during synthesis and affects downstream pathways like cell signaling and immune response.
Specifications
Form
Lyophilized
General info
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed : 31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Sequence similarities
Belongs to the SWP1 family.
Target data
Complementary Products
Product promise
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