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AB102557

Recombinant Human RPP30 protein

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Recombinant Human RPP30 protein is a Human Full Length protein, in the 1 to 268 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

RNASEP2, RPP30, Ribonuclease P protein subunit p30, RNaseP protein p30, RNase P subunit 2

1 Images
SDS-PAGE - Recombinant Human RPP30 protein (AB102557)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human RPP30 protein (AB102557)

15% SDS-PAGE analysis of ab102557 (3 μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P78346

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0292% EDTA

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAVFADLDLRAGSDLKALRGLVETAAHLGYSVVAINHIVDFKEKKQEIEKPVAVSELFTTLPIVQGKSRPIKILTRLTIIVSDPSHCNVLRATSSRARLYDVVAVFPKTEKLFHIACTHLDVDLVCITVTEKLPFYFKRPPINVAIDRGLAFELVYSPAIKDSTMRRYTISSALNLMQICKGKNVIISSAAERPLEIRGPYDVANLGLLFGLSESDAKAAVSTNCRAALLHGETRKTAFGIISTVKKPRPSEGDEDCLPASKKAKCEG","proteinLength":"Full Length","predictedMolecularWeight":"31.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":268,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P78346","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPP30 also known as Ribonuclease P protein subunit p30 is a protein involved in the enzymatic process that removes 5' leader sequences from precursor tRNA molecules. It has a mass of approximately 25 kDa. RPP30 is expressed in various tissues across the human body indicating its fundamental role in RNA processing.
Biological function summary

RPP30 plays a role as part of the Ribonuclease P complex which is important for the maturation of tRNA. The Ribonuclease P complex contains both RNA and protein components and RPP30 interacts with other subunits to form the complete ribonucleoprotein complex. This association is necessary for catalytic activity and stability of the complex.

Pathways

RPP30 is involved in RNA processing pathways important for cell viability. Specifically it is part of the tRNA processing pathway working alongside proteins like RPP14 and POP1 to assist in the maturation of tRNA. These interactions emphasize the integration of RPP30 in important cellular processes that affect protein synthesis.

Involvement of RPP30 in certain autoimmune conditions has been noted. Altered expression of RPP30 and its associated complex proteins can contribute to autoimmune diseases like systemic sclerosis. Additionally aberrations in RPP30 expression or function have been linked with alterations in RNA processing pathways that may impact cell proliferation and survival further showing connections to these disease states.
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Specifications

Form

Liquid

Additional notes

ab102557 was purified using conventional chromatography techniques.

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General info

Function

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed : 30454648, PubMed : 9037013, PubMed : 9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed : 28115465).

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed : 30454648, PubMed : 9037013, PubMed : 9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed : 28115465).
See full target information RPP30
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