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AB240762

Recombinant Human RPS13 protein (Tagged)

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Recombinant Human RPS13 protein (Tagged) is a Human Fragment protein, in the 3 to 151 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Small ribosomal subunit protein uS15, 40S ribosomal protein S13, RPS13

1 Images
SDS-PAGE - Recombinant Human RPS13 protein (Tagged) (AB240762)
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Supplier Data

SDS-PAGE - Recombinant Human RPS13 protein (Tagged) (AB240762)

ab240762 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P62277

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"RMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA","proteinLength":"Fragment","predictedMolecularWeight":"44 kDa","actualMolecularWeight":null,"aminoAcidEnd":151,"aminoAcidStart":3,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P62277","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPS13 also known as Ribosomal Protein S13 is a component of the small 40S subunit of the ribosome. This protein has a mass of around 17 kDa and resides in the cytoplasm where the protein synthesis occurs. RPS13 plays a mechanical role in the translation process by interacting with rRNA and other ribosomal proteins to form the ribosomal small subunit. This interaction is essential for maintaining the stability and function of ribosomes during protein translation.
Biological function summary

The involvement of RPS13 extends to its role as a part of the ribosomal complex. It participates actively in translating mRNA into proteins by providing structural support and interacting with translation factors. Although expressed ubiquitously higher expression levels appear in tissues with rapid cell turnover like the bone marrow and the gastrointestinal tract. RPS13 contributes to cellular proliferation and growth by supporting efficient protein synthesis.

Pathways

RPS13 is integral to ribosome biogenesis and protein synthesis pathways. In the ribosome assembly pathway it works alongside other ribosomal proteins like RPS4 and RPS6 ensuring the proper formation and function of the 40S subunit. Moreover RPS13 interacts with the mTOR signaling pathway which regulates protein synthesis cell growth and proliferation. This connection links RPS13 to various signaling networks that control cellular homeostasis and metabolism.

Mutations or dysregulation of RPS13 have associations with cancer and Diamond-Blackfan Anemia. In cancer altered expression of RPS13 can influence cell proliferation and tumor growth due to its central role in protein synthesis. RPS13’s interaction with tumor suppressor proteins like p53 highlights its potential involvement in oncogenic pathways. In Diamond-Blackfan Anemia defects in ribosomal proteins including RPS13 lead to impaired erythropoiesis and anemia suggesting its critical role in red blood cell maturation and function.
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Specifications

Form

Liquid

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General info

Function

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797).

Sequence similarities

Belongs to the universal ribosomal protein uS15 family.

Post-translational modifications

Ubiquitinated at Lys-27 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).

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Product protocols

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Target data

Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797).
See full target information RPS13
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