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AB151818

Recombinant Human RPS19 protein

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Recombinant Human RPS19 protein is a Human Full Length protein, in the 2 to 145 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

Small ribosomal subunit protein eS19, 40S ribosomal protein S19, RPS19

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

P39019

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

storage-buffer

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Complementary Products

Reagents, Controls & Accessories

AB116027

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB116027)

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  • 2
Primary Antibodies

AB181365

Anti-RPS19 antibody [EPR10423]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPS19 antibody [EPR10423] (AB181365)

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  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"PGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH","proteinLength":"Full Length","predictedMolecularWeight":"15.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":145,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P39019","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPS19 also known as Ribosomal Protein S19 is a component of the small 40S ribosomal subunit. It has a molecular weight of approximately 16 kDa. This protein is widely expressed in many tissues including the bone marrow and spleen which are important for hematopoiesis. RPS19 plays a mechanical role in ensuring the formation and function of ribosomes which are essential for protein synthesis. By participating in ribosome assembly it supports the translational machinery of cells.
Biological function summary

Ribosomal protein S19 holds a critical place in ribosome biogenesis. It is part of the ribosomal protein family and works together with other ribosomal proteins to create functional ribosomes necessary for cellular protein synthesis. As part of the 40S ribosomal subunit RPS19 facilitates the accurate translation of mRNA into proteins which is fundamental for cell growth and proliferation. The 40S subunit alongside the 60S subunit completes the formation of the functional ribosome.

Pathways

Ribosomal protein S19 contributes to the essential process of translation an important pathway within cell biology. It plays a part in the ribosome assembly pathway a pivotal process necessary for cell survival and function. RPS19 interacts closely with other ribosomal proteins such as RPS24 and RPS14 ensuring the proper assembly and functionality of the ribosomal subunits. These interactions are integral to maintaining cellular homeostasis and protein production.

Ribosomal protein S19 is associated with Diamond-Blackfan Anemia a rare genetic anemia caused by ribosomal protein mutations. This condition arises due to defective ribosome biogenesis leading to impaired erythropoiesis. Mutations in RPS19 reduce the ribosome's capacity to synthesize proteins specifically affecting red blood cell production. Additionally the protein is related to other ribosomal anomalies that connect to various bone marrow failure syndromes.
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Specifications

Form

Lyophilized

Additional notes

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Component of the small ribosomal subunit (PubMed : 23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed : 16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797).

Sequence similarities

Belongs to the eukaryotic ribosomal protein eS19 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of the small ribosomal subunit (PubMed : 23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 23636399). Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed : 16990592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797).
See full target information 40S ribosomal protein S19
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