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AB117224

Recombinant Human RPS7 protein

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Recombinant Human RPS7 protein is a Human Full Length protein, in the 1 to 194 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Small ribosomal subunit protein eS7, 40S ribosomal protein S7, RPS7

1 Images
SDS-PAGE - Recombinant Human RPS7 protein (AB117224)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RPS7 protein (AB117224)

15% SDS-PAGE showing ab117224 at approximately 24.7kDa (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P62081

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL","proteinLength":"Full Length","predictedMolecularWeight":"24.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":194,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P62081","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RPS7 also known as Ribosomal Protein S7 plays an important role in protein synthesis as a component of the ribosome. It is a structural protein with a mass of approximately 22 kDa and is expressed ubiquitously across different tissues. Within the ribosome RPS7 belongs to the small 40S subunit where it works alongside other ribosomal proteins and rRNA to contribute to the assembly and function of the ribosome during translation.
Biological function summary

RPS7 facilitates the translation process by stabilizing rRNA and ensuring correct assembly of the ribosomal subunits. As one of the ribosomal proteins it is essential for maintaining ribosome integrity and function within the ribosomal complex. Through interactions with rRNA and other ribosomal proteins RPS7 aids in the translational accuracy and efficiency ultimately influencing protein synthesis rates in cells.

Pathways

RPS7 participates importantly in the translation machinery within cells. It forms part of the ribosome which serves as a central platform for the mRNA translation pathway. As an integral component of ribosomal pathways RPS7 interacts with other key proteins like RPL and EIF families which assist in translation initiation elongation and termination processes. The involvement of RPS7 in these pathways supports cellular protein homeostasis and gene expression regulation.

RPS7 has been linked to Diamond-Blackfan anemia a condition characterized by defective ribosomal protein production leading to bone marrow failure. Mutations in RPS7 and similar ribosomal proteins such as RPS19 impact ribosome biogenesis disrupting normal erythropoiesis and causing anemia. Additionally upregulation of RPS7 has been observed in some cancers where altered protein synthesis contributes to tumorigenesis and tumor growth.
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Specifications

Form

Liquid

Additional notes

ab117224 is purified using conventional chromatography techniques.

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General info

Function

Component of the small ribosomal subunit (PubMed : 23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 23636399). Required for rRNA maturation (PubMed : 19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797).

Sequence similarities

Belongs to the eukaryotic ribosomal protein eS7 family.

Post-translational modifications

Phosphorylated by NEK6.. Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization.

Subcellular localisation

Cytoskeleton

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the small ribosomal subunit (PubMed : 23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 23636399). Required for rRNA maturation (PubMed : 19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797).
See full target information RPS7
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Product promise

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For full details, please see our Terms & Conditions
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