Recombinant Human RRAGC protein
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Recombinant Human RRAGC protein is a Human Full Length protein, in the 1 to 399 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Ras-related GTP-binding protein C, Rag C, RagC, GTPase-interacting protein 2, TIB929, RRAGC
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human RRAGC protein (AB123171)
15% SDS-PAGE showing ab123171 (3µg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RRAGC forms a part of the heterodimeric Rag GTPase complex often teaming with its partner RRAGB. This complex acts as an important regulator in the mTORC1 signaling pathway influencing nutrient sensing and energy balance within cells. RRAGC's ability to toggle between different energy states allows it to contribute to cellular metabolism and response to external stress.
Pathways
RRAGC engages directly in the mTOR signaling pathway an important driver of cell growth and proliferation. It interacts closely with related proteins such as Raptor and mTOR kinase forming a bridge between amino acid availability and cellular growth signals. Additionally RRAGC's role connects to the autophagy pathway affecting cellular degradation processes and nutrient recycling under nutrient-deprived conditions.
Specifications
Form
Liquid
Additional notes
ab123171 is purified using conventional chromatography techniques.
General info
Function
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373, PubMed : 31601708, PubMed : 31601764, PubMed : 32612235, PubMed : 34071043, PubMed : 36697823, PubMed : 37057673). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form : RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed : 24095279, PubMed : 31601708, PubMed : 31601764, PubMed : 32868926). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373, PubMed : 32612235, PubMed : 36697823). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed : 20381137, PubMed : 24095279, PubMed : 27234373). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3 : GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed : 32612235, PubMed : 36697823).
Sequence similarities
Belongs to the GTR/RAG GTP-binding protein family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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