Recombinant Human RRP41 protein (denatured) (His tag N-Terminus)
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Recombinant Human RRP41 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 245 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
RRP41, SKI6, EXOSC4, Exosome complex component RRP41, Exosome component 4, Ribosomal RNA-processing protein 41, p12A
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human RRP41 protein (denatured) (His tag N-Terminus) (AB176048)
SDS-PAGE analysis of ab176048 (3µg).
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RRP41 participates in RNA metabolism by aiding in the degradation of various RNA species. It is a component of the exosome complex which consists of several other subunits working together to process RNA. This complex is vital in maintaining RNA homeostasis allowing cells to regulate gene expression effectively. RRP41's role in the exosome ensures proper processing of ribosomal RNA (rRNA) messenger RNA (mRNA) and other RNA molecules.
Pathways
RRP41 functions within the RNA surveillance pathway. This pathway helps identify and eliminate defective RNA therefore ensuring RNA quality control within the cell. Additionally it interacts with other proteins such as RRP42 and RRP43 which are also part of the exosome complex. The interaction between these proteins is important in regulating RNA degradation and processing functions safeguarding the precision of cellular activities.
Specifications
Form
Liquid
General info
Function
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.
Sequence similarities
Belongs to the RNase PH family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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