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AB162810

Recombinant Human RSBN1/Rosbin protein (GST tag N-Terminus)

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Recombinant Human RSBN1/Rosbin protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 411 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KDM9, RSBN1, Lysine-specific demethylase 9, Round spermatid basic protein 1

1 Images
SDS-PAGE - Recombinant Human RSBN1/Rosbin protein (GST tag N-Terminus) (AB162810)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RSBN1/Rosbin protein (GST tag N-Terminus) (AB162810)

ab162810 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q5VWQ0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as RSBN1.
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Sequence info

[{"sequence":"MAAQVGAVRVVRAVAAQEEPDKEGKEKPHAGVSPRGVKRQRRSSSGGSQEKRGRPSQEPPLAPPHRRRRSRQHPGPLPPTNAAPTVPGPVEPLLLPPPPPPSLAPAGPAVAAPLPAPSTSALFTFSPLTVSAAGPKHKGHKERHKHHHHRGPDGDPSSCGTDLKHKDKQENGERTGGVPLIKAPKRETPDENGKTQRADDFVLKKIKKKKKKKHREDMRGRRLKMYNKEVQTVCAGLTRISKEILTQGQINSTSGLNKESFRYLKDEQLCRLNLGMQEYRVPQGVQTPFMTHQEHSIRRNFLKTGTKFSNFIHEEHQSNGGALVLHAYMDELSFLSPMEMERFSEEFLALTFSENEKNAAYYALAIVHGAAAYLPDFLDYFAFNFPNTPVKMEILGKKDIETTTISNFHTQ","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":411,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q5VWQ0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RSBN1 also known as Rosbin encodes a protein involved in regulating structures within the cell nucleus. RSBN1 has a mass of approximately 94 kDa and is predominantly expressed in tissues with rapidly dividing cells such as the testis and certain cancerous tissues. This protein localizes mainly in the nucleoplasm indicating its role in nuclear processes. Its function and localization suggest it as a potential player in maintaining nuclear architecture and chromatin organization.
Biological function summary

The protein encoded by RSBN1 participates in chromatin remodeling which is essential for gene expression regulation and DNA replication. It acts as part of a larger chromatin-associated complex where it supports the structural changes needed for efficient transcription and replication processes. By modulating chromatin accessibility RSBN1 influences cell cycle progression affecting cell proliferation.

Pathways

RSBN1 plays a role in the chromatin organization pathway and cell cycle regulation. It interacts with histone modification enzymes facilitating the deposition of histone marks that modify chromatin structure. RSBN1 is associated with proteins like ATRX that have roles in chromatin remodeling and telomere maintenance contributing to genomic stability during cell division.

RSBN1 has shown a link to cancer progression particularly in testicular and digestive system cancers. Alterations in RSBN1 expression or function lead to disrupted chromatin organization resulting in uncontrolled cell proliferation a hallmark of cancer. The interaction with ATRX and other chromatin-modifying proteins further connects RSBN1 to these malignancies with potential implications in tumor progression and treatment resistance.
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Specifications

Form

Liquid

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General info

Function

Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2) and trimethylated 'Lys-20' of histone H4 (H4K20me3) into monomethyl H4K20 (H4K20me1) thereby modulating chromosome architecture. May play a critical role in regulating H4K20 methylation during spermatogenesis.

Sequence similarities

Belongs to the round spermatid basic protein 1 family.

Post-translational modifications

Phosphorylated by PKA.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2) and trimethylated 'Lys-20' of histone H4 (H4K20me3) into monomethyl H4K20 (H4K20me1) thereby modulating chromosome architecture. May play a critical role in regulating H4K20 methylation during spermatogenesis.
See full target information RSBN1
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