Recombinant Human rSec6 protein is a Human Full Length protein, in the 1 to 745 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M K E T D R E A V A T A V Q R V A G M L Q R P D Q L D K V E Q Y R R R E A R K K A S V E A R L K A A I Q S Q L D G V R T G L S Q L H N A L N D V K D I Q Q S L A D V S K D W R Q S I N T I E S L K D V K D A V V Q H S Q L A A A V E N L K N I F S V P E I V R E T Q D L I E Q G A L L Q A H R K L M D L E C S R D G L M Y E Q Y R M D S G N T R D M T L I H G Y F G S T Q G L S D E L A K Q L W M V L Q R S L V T V R R D P T L L V S V V R I I E R E E K I D R R I L D R K K Q T G F V P P G R P K N W K E K M F T I L E R T V T T R I E G T Q A D T R E S D K M W L V R H L E I I R K Y V L D D L I V A K N L M V Q C F P P H Y E I F K N L L N M Y H Q A L S T R M Q D L A S E D L E A N E I V S L L T W V L N T Y T S T E M M R N V E L A P E V D V G T L E P L L S P H V V S E L L D T Y M S T L T S N I I A W L R K A L E T D K K D W V K E T E P E A D Q D G Y Y Q T T L P A I V F Q M F E Q N L Q V A A Q I S E D L K T K V L V L C L Q Q M N S F L S R Y K D E A Q L Y K E E H L R N R Q H P H C Y V Q Y M I A I I N N C Q T F K E S I V S L K R K Y L K N E V E E G V S P S Q P S M D G I L D A I A K E G C S G L L E E V F L D L E Q H L N E L M T K K W L L G S N A V D I I C V T V E D Y F N D F A K I K K P Y K K R M T A E A H R R V V V E Y L R A V M Q K R I S F R S P E E R K E G A E K M V R E A E Q L R F L F R K L A S G F G E D V D G Y C D T I V A V A E V I K L T D P S L L Y L E V S T L V S K Y P D I R D D H I G A L L A V R G D A S R D M K Q T I M E T L E Q G P A Q A S P S Y V P L F K D I V V P S L N V A K L L K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Alternative names
SEC6, SEC6L1, EXOC3, Exocyst complex component 3, Exocyst complex component Sec6
Recommended products
Recombinant Human rSec6 protein is a Human Full Length protein, in the 1 to 745 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- O60645-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M K E T D R E A V A T A V Q R V A G M L Q R P D Q L D K V E Q Y R R R E A R K K A S V E A R L K A A I Q S Q L D G V R T G L S Q L H N A L N D V K D I Q Q S L A D V S K D W R Q S I N T I E S L K D V K D A V V Q H S Q L A A A V E N L K N I F S V P E I V R E T Q D L I E Q G A L L Q A H R K L M D L E C S R D G L M Y E Q Y R M D S G N T R D M T L I H G Y F G S T Q G L S D E L A K Q L W M V L Q R S L V T V R R D P T L L V S V V R I I E R E E K I D R R I L D R K K Q T G F V P P G R P K N W K E K M F T I L E R T V T T R I E G T Q A D T R E S D K M W L V R H L E I I R K Y V L D D L I V A K N L M V Q C F P P H Y E I F K N L L N M Y H Q A L S T R M Q D L A S E D L E A N E I V S L L T W V L N T Y T S T E M M R N V E L A P E V D V G T L E P L L S P H V V S E L L D T Y M S T L T S N I I A W L R K A L E T D K K D W V K E T E P E A D Q D G Y Y Q T T L P A I V F Q M F E Q N L Q V A A Q I S E D L K T K V L V L C L Q Q M N S F L S R Y K D E A Q L Y K E E H L R N R Q H P H C Y V Q Y M I A I I N N C Q T F K E S I V S L K R K Y L K N E V E E G V S P S Q P S M D G I L D A I A K E G C S G L L E E V F L D L E Q H L N E L M T K K W L L G S N A V D I I C V T V E D Y F N D F A K I K K P Y K K R M T A E A H R R V V V E Y L R A V M Q K R I S F R S P E E R K E G A E K M V R E A E Q L R F L F R K L A S G F G E D V D G Y C D T I V A V A E V I K L T D P S L L Y L E V S T L V S K Y P D I R D D H I G A L L A V R G D A S R D M K Q T I M E T L E Q G P A Q A S P S Y V P L F K D I V V P S L N V A K L L K
- Accession
- O60645
- Protein length
- Full Length
- Amino acids
- 1 to 745
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
- Sequence similarities
Belongs to the SEC6 family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein rSec6 also known as Sec6 is an integral component of the exocyst complex which plays a role in the targeting and tethering of secretory vesicles to specific sites on the plasma membrane. It has an estimated molecular mass of approximately 97 kDa. rSec6 is expressed across a range of tissue types and is especially noted in actively secreting cells such as those found in neuronal and epithelial tissues.
- Biological function summary
RSec6 facilitates the assembly of the exocyst complex which comprises eight proteins and functions in the later stages of the exocytosis pathway. This complex is essential for vesicle fusion and proper secretion processes. By interacting with other exocyst components rSec6 ensures accurate delivery of vesicles containing proteins lipids and other molecules necessary for cell communication and maintenance.
- Pathways
RSec6 plays a significant role in both the exocytosis and vesicle transport pathways. The exocyst complex including rSec6 is critical for the vesicle docking and fusion process. rSec6 interacts closely with other exocyst proteins such as Sec5 and Sec8 in these pathways collectively ensuring that vesicles are correctly tethered to areas of active secretion.
- Associated diseases and disorders
RSec6 shows involvement in conditions such as diabetes and some neuronal disorders. Disruption or misregulation of the exocyst complex wherein rSec6 plays a part affects insulin secretion relating to diabetes. Additionally altered rSec6 function can associate with neurodegenerative diseases due to its importance in neuronal cell signaling. The interaction between rSec6 and proteins such as Munc18 and SNAREs is vital in these contexts as these proteins cooperate closely in vesicle fusion processes implicated in several pathophysiological states.
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1 product image
SDS-PAGE - Recombinant Human rSec6 protein (ab153182)
ab153182 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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