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AB139230

Recombinant Human RSG1 protein

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Recombinant Human RSG1 protein is a Human Full Length protein, in the 1 to 258 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C1orf89, RSG1, CPLANE2, Ciliogenesis and planar polarity effector 2, REM2- and Rab-like small GTPase 1

1 Images
SDS-PAGE - Recombinant Human RSG1 protein (AB139230)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human RSG1 protein (AB139230)

15% SDS-PAGE analysis of 3 µg ab139230.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9BU20

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8.5 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMARPPVPGSVVVPNWHESAEGKEYLACILRKNRRRVFGLLERPVLLPPVSIDTASYKIFVSGKSGVGKTALVAKLAGLEVPVVHHETTGIQTTVVFWPAKLQASSRVVMFRFEFWDCGESALKKFDHMLLACMENTDAFLFLFSFTDRASFEDLPGQLARIAGEAPGVVRMVIGSKFDQYMHTDVPERDLTAFRQAWELPLLRVKSVPGRRLADGRTLDGRAGLADVAHILNGLAEQLWHQDQVAAGLLPNPPESAPE","proteinLength":"Full Length","predictedMolecularWeight":"30.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":258,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BU20","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RSG1 also known as REM2 and GEM-interacting protein is a GTP-binding protein with a molecular mass of approximately 30 kDa. It is found in various tissues with significant expression in the brain and reproductive organs. RSG1 operates mechanically by regulating small GTPases that influence intracellular signaling pathways involving protein-protein interactions. This protein takes part in controlling cytoskeletal dynamics due to its GTPase activity.
Biological function summary

Small GTPase proteins like RSG1 play a role in processes such as cell growth cytoskeletal organization and neural development. RSG1 functions as part of GTPase complexes which are essential for signal transduction and cellular morphology adjustments. This protein contributes critically to the regulation of intracellular movement and neural cell signaling affecting neuron structures and functions.

Pathways

The RSG1 protein is involved in the Rho and Ras signaling pathways which control cell shape and growth. RSG1 interacts with other proteins such as RAC1 and RhoA modulating actin cytoskeleton dynamics and impacting cellular motility. Within these pathways RSG1 facilitates the relay of signals from extracellular stimuli to cellular responses essential for maintaining structural integrity and cellular functions.

RSG1 has been linked to certain neurological disorders and cancer types due to its regulatory function in cell signaling. Abnormal levels or mutations in RSG1 may disrupt cellular communication contributing to conditions such as glioma and neurodevelopmental disorders. Research indicates an interaction between RSG1 and mutated forms of other GTPases which can contribute to malignancies and developmental anomalies. Understanding RSG1 involvement can provide insights into the development and progression of these conditions.
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Specifications

Form

Liquid

Additional notes

ab139230 is purified using conventional chromatography techniques.

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General info

Function

Required for efficient primary cilia initiation, regulating a late step in cilia initiation. Plays a role in the final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axoneme.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Required for efficient primary cilia initiation, regulating a late step in cilia initiation. Plays a role in the final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axoneme.
See full target information CPLANE2
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