Recombinant human RSK4 protein (Active)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RSK4 also known as Ribosomal S6 Kinase 4 or RPS6KA6 is a protein that functions as a serine/threonine kinase. It plays a significant role in intracellular signaling. RSK4 has a molecular mass of approximately 80 kDa. It belongs to the RSK family of proteins which share a characteristic kinase domain structure. Expression of RSK4 is seen in various tissues including brain kidney and endothelial cells indicating its diverse functional roles across different cell types and systems.

Biological function summary

RSK4 has a role in regulating cell growth and survival. It can influence transcriptional processes and protein synthesis. Despite being not extensively documented in biological research as other family members its kinase activity suggests that it participates in various cellular processes by phosphorylating specific substrates. RSK4 operates as an individual kinase while its related family members may form complexes for more coordinated activities. Its action in cell cycle regulation highlights its importance in maintaining cellular function.

Pathways

RSK4 integrates into well-known signaling pathways including the MAPK/ERK pathway. This association implies it has a role in the regulation of gene expression mitosis and cell survival linking it with other kinases like ERK1 and ERK2. Furthermore it can interact with pathways involving the PI3K/AKT signaling cascade contributing to additional regulation of cell growth thereby influencing diverse physiological functions. The involvement of RSK4 in these pathways highlights its potential interactions with other proteins such as MEK and mTOR which are pivotal in driving intracellular responses.

RSK4 has associations with various conditions including cancer and specific genetic disorders. It has been linked with tumor suppression suggesting that dysregulation of RSK4 may contribute to oncogenic processes. Additionally alterations in RSK4 expression or activity have potential connections with mental health disorders due to its expression in the brain. It interacts biologically with proteins like p53 and other growth factor receptors which are also implicated in these disease processes. Understanding RSK4's role in these contexts can provide insights into therapeutic targets for managing such conditions.