Recombinant Human RTCD1 protein (His tag N-Terminus)
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Recombinant Human RTCD1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 366 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
RPC, RPC1, RTC1, RTCD1, RTCA, RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase, RNA terminal phosphate cyclase domain-containing protein 1, RTC domain-containing protein 1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human RTCD1 protein (His tag N-Terminus) (AB181893)
SDS-PAGE analysis of ab181893 (3µg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The RTCD1 enzyme participates in the formation of RNA 2'3'-cyclic phosphates which are important intermediates in several RNA processing pathways. Studies indicate that its catalytic activity contributes to RNA splicing a critical step in RNA maturation. Although RTCD1 itself does not form part of a larger protein complex its activity influences the function of other proteins involved in post-transcriptional gene expression regulation.
Pathways
RNA processing mechanisms significantly involve RTCD1's enzymatic activity. Specifically it participates in RNA splicing and RNA capping pathways. These pathways influence expression and function of several other regulatory proteins. Researchers have identified connections between RTCD1 and other core RNA processing proteins such as spliceosomal components within these pathways further highlighting RTCD1's role in complex regulatory networks.
Specifications
Form
Liquid
Additional notes
ab181893 was purified using conventional chromatography techniques.
General info
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (PubMed : 9184239). The mechanism of action of the enzyme occurs in 3 steps : (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (PubMed : 9184239). Likely functions in some aspects of cellular RNA processing (PubMed : 25961792, PubMed : 9184239). Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury (PubMed : 25961792).
Sequence similarities
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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