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AB116191

Recombinant Human RTN4IP1 protein

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Recombinant Human RTN4IP1 protein is a Human Full Length protein, in the 41 to 396 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

NIMP, RTN4IP1, NOGO-interacting mitochondrial protein

1 Images
SDS-PAGE - Recombinant Human RTN4IP1 protein (AB116191)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RTN4IP1 protein (AB116191)

15% SDS-PAGE analysis of 3 μg ab116191.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q8WWV3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSTVMPAWVIDKYGKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSGYGATALNMKRDPLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLNDKNCTGKRVLILGASGGVGTFAIQVMKAWDAHVTAVCSQDASELVRKLGADDVIDYKSGSVEEQLKSLKPFDFILDNVGGSTETWAPDFLKKWSGATYVTLVTPFLLNMDRLGIADGMLQTGVTVGSKALKHFWKGVHYRWAFFMASGPCLDDIAELVDAGKIRPVIEQTFPFSKVPEAFLKVERGHARGKTVINVV","proteinLength":"Full Length","predictedMolecularWeight":"41.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":396,"aminoAcidStart":41,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WWV3","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RTN4IP1 also known as NIMP or OPA10 is a mitochondrial protein with a molecular weight of approximately 48 kDa. This protein is expressed in various tissues with higher levels observed in the brain and muscle tissues. Mechanically RTN4IP1 interacts with several mitochondrial-related proteins contributing to processes like cellular respiration and energy production. It is considered important for maintaining mitochondrial function and structure.
Biological function summary

The function of RTN4IP1 involves its role in mitochondrial dynamics and energy metabolism. It is a part of a multi-protein complex that includes members of the reticulon family which contribute to the shaping of the mitochondrial network. This complex interaction is essential for optimal oxidative phosphorylation a process that converts nutrients into ATP the cell’s main energy currency. RTN4IP1's influence extends to the regulation of reactive oxygen species ensuring cellular homeostasis.

Pathways

RTN4IP1 plays a significant role in both the mitochondrial fission and fusion process and the oxidative phosphorylation pathway. Mitochondrial fission-fusion dynamics are critical for cellular health and are tightly regulated by interactions with proteins such as mitofusin and dynamin-related protein 1 (DRP1). In the oxidative phosphorylation pathway RTN4IP1’s activity intersects with complexes that include NADH dehydrogenase and cytochrome c oxidase. These interactions help maintain efficient electron transport which is essential for ATP synthesis.

RTN4IP1 has connections to neurodegenerative disorders and mitochondrial myopathies. Diseases like hereditary spastic paraplegia can occur due to dysfunction in this protein’s mitochondrial roles leading to impaired energy metabolism. Mutations impacting RTN4IP1 are associated with optic atrophy where it interacts with optic atrophy 1 (OPA1) another protein linked to mitochondrial dysfunction. These connections highlight the protein's importance in maintaining neural and muscular function and highlight its potential as a target for therapeutic interventions.
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Specifications

Form

Liquid

Additional notes

ab116191 was purified using conventional chromatography.

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General info

Function

Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Subcellular localisation

Mitochondrion outer membrane

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Product protocols

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Target data

Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.
See full target information RTN4IP1
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Complementary Products

Primary Antibodies

AB155304

Anti-RTN4IP1 antibody

Western blot - Anti-RTN4IP1 antibody (AB155304)

  • 0
  • 0
Primary Antibodies

AB171978

Anti-TIMMDC1/C3orf1 antibody [EPR11807]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-TIMMDC1/C3orf1 antibody [EPR11807] (AB171978)

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Proteins & Peptides

AB101155

Recombinant Human PHAP1 protein

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Assay Kits

AB267631

Human HGFA ELISA Kit

Sandwich ELISA - Human HGFA ELISA Kit (AB267631)

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