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AB187417

Recombinant Human RTP4 protein (Cytoplasmic domain) (His tag N-Terminus)

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Recombinant Human RTP4 protein (Cytoplasmic domain) (His tag N-Terminus) is a Human Fragment protein, in the 1 to 224 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

IFRG28, Z3CXXC4, RTP4, Receptor-transporting protein 4, 28 kDa interferon-responsive protein, 3CxxC-type zinc finger protein 4

1 Images
SDS-PAGE - Recombinant Human RTP4 protein (Cytoplasmic domain) (His tag N-Terminus) (AB187417)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human RTP4 protein (Cytoplasmic domain) (His tag N-Terminus) (AB187417)

15% SDS-PAGE analysis of ab187417 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q96DX8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMVVDFWTWEQTFQELIQEAKPRATWTLKLDGNLQLDCLAQGWKQYQQRAFGWFRCSSCQRSWASAQVQILCHTYWEHWTSQGQVRMRLFGQRCQKCSWSQYEMPEFSSDSTMRILSNLVQHILKKYYGNGTRKSPEMPVILEVSLEGSHDTANCEACTLGICGQGLKSCMTKPSKSLLPHLKTGNSSPGIGAVYLANQAKNQSAEAKEAKGSGYEKLGPSRDPD","proteinLength":"Fragment","predictedMolecularWeight":"27.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":224,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96DX8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RTP4 also known as Receptor Transporter Protein 4 plays a significant role in the endoplasmic reticulum where it facilitates the trafficking and proper function of olfactory receptors. It has a molecular mass of approximately 31 kDa. RTP4 expression is mainly found in the olfactory sensory neurons but also in various other tissues such as the brain and liver. It helps in guiding G protein-coupled receptors (GPCRs) to the cell membrane ensuring their functional expression.
Biological function summary

The RTP4 protein aids in the transport and functional expression of GPCRs without forming part of any known stable complexes. This chaperone activity is vital for GPCR function impacting signal transduction by promoting proper receptor folding and surface expression. RTP4 ensures that olfactory and other related receptors can adequately respond to stimuli. Its chaperone activity is important for maintaining GPCR dynamics in various cell types.

Pathways

RTP4 significantly influences GPCR signaling pathways and olfactory signaling pathways. It directly affects the transport and activation of olfactory receptors key components in the olfactory signaling pathway. RTP4's interaction with olfactory receptors impacts the downstream components such as adenylyl cyclase leading to successful signal transduction. Additionally RTP4 interacts with proteins in GPCR signaling that modify receptor availability on the cell surface.

RTP4 has implications in anosmia the loss or impairment of the sense of smell and potentially in liver-related disorders. Disruption of RTP4 function can lead to defective olfactory receptor trafficking resulting in anosmia. RTP4-related pathways implicate proteins like OR51E1 in olfactory dysfunctions. There may be a less clear association with liver disorders involving misfolded GPCRs; however this link requires further exploration.
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Specifications

Form

Liquid

Additional notes

ab187417 was purified using conventional chromatography techniques.

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General info

Function

Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed : 16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).

Sequence similarities

Belongs to the TMEM7 family.

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Product protocols

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Target data

Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed : 16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).
See full target information RTP4
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