Recombinant Human RTR protein is a Human Full Length protein, in the 1 to 475 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M E R D E P P P S G G G G G G G S A G F L E P P A A L P P P P R N G F C Q D E L A E L D P G T N D R A E Q R T C L I C G D R A T G L H Y G I I S C E G C K G F F K R S I C N K R V Y R C S R D K N C V M S R K Q R N R C Q Y C R L L K C L Q M G M N R K A I R E D G M P G G R N K S I G P V Q I S E E E I E R I M S G Q E F E E E A N H W S N H G D S D H S S P G N R A S E S N Q P S P G S T L S S R S V E L N G F M A F R E Q Y M G M S V P P H Y Q Y I P H L F S Y S G H S P L L P Q Q A R S L D P Q S Y S L I H Q L L S A E D L E P L G T P M L I E D G Y A V T Q A E L F A L L C R L A D E L L F R Q I A W I K K L P F F C E L S I K D Y T C L L S S T W Q E L I L L S S L T V Y S K Q I F G E L A D V T A K Y S P S D E E L H R F S D E G M E V I E R L I Y L Y H K F H Q L K V S N E E Y A C M K A I N F L N Q D I R G L T S A S Q L E Q L N K R Y W Y I C Q D F T E Y K Y T H Q P N R F P D L M M C L P E I R Y I A G K M V N V P L E Q L P L L F K V V L H S C K T S V G K E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes Recombinant protein |
Target data
Function
Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).
Alternative names
GCNF, NR6A1, Nuclear receptor subfamily 6 group A member 1, Germ cell nuclear factor, Retinoid receptor-related testis-specific receptor, hGCNF, RTR, hRTR
Recommended products
Recombinant Human RTR protein is a Human Full Length protein, in the 1 to 475 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- Q15406-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
- M E R D E P P P S G G G G G G G S A G F L E P P A A L P P P P R N G F C Q D E L A E L D P G T N D R A E Q R T C L I C G D R A T G L H Y G I I S C E G C K G F F K R S I C N K R V Y R C S R D K N C V M S R K Q R N R C Q Y C R L L K C L Q M G M N R K A I R E D G M P G G R N K S I G P V Q I S E E E I E R I M S G Q E F E E E A N H W S N H G D S D H S S P G N R A S E S N Q P S P G S T L S S R S V E L N G F M A F R E Q Y M G M S V P P H Y Q Y I P H L F S Y S G H S P L L P Q Q A R S L D P Q S Y S L I H Q L L S A E D L E P L G T P M L I E D G Y A V T Q A E L F A L L C R L A D E L L F R Q I A W I K K L P F F C E L S I K D Y T C L L S S T W Q E L I L L S S L T V Y S K Q I F G E L A D V T A K Y S P S D E E L H R F S D E G M E V I E R L I Y L Y H K F H Q L K V S N E E Y A C M K A I N F L N Q D I R G L T S A S Q L E Q L N K R Y W Y I C Q D F T E Y K Y T H Q P N R F P D L M M C L P E I R Y I A G K M V N V P L E Q L P L L F K V V L H S C K T S V G K E
- Accession
- Q15406
- Protein length
- Full Length
- Predicted molecular weight
- 80.9 kDa
- Amino acids
- 1 to 475
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).
- Sequence similarities
Belongs to the nuclear hormone receptor family. NR6 subfamily.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RTR also known as Retinoid Receptor is a transcription factor involved in regulating gene expression. Its molecular weight is approximately 55 kDa. RTR is expressed in various tissues with high expression levels found in liver brain and kidney. It binds to specific DNA sequences to control the transcription of genes related to cell differentiation and lipid metabolism. RTR belongs to the nuclear receptor superfamily indicating its role in responding to metabolic cues.
- Biological function summary
RTR functions as an integral part of gene regulation networks by forming heterodimers with other nuclear receptors such as RXR (retinoid X receptor). This dimerization is necessary for binding to response elements in the DNA which modulates the transcription of target genes. The RTR-RXR complex plays an important role in cellular processes including development homeostasis and metabolism regulation impacting how cells respond to retinoic acid and other ligands.
- Pathways
RTR plays significant roles in the retinoic acid signaling and lipid metabolism pathways. In the retinoic acid signaling pathway RTR regulates gene expression that is critical for embryonic development and cell differentiation. Through its interaction with other proteins like RXR RTR impacts the initiation of transcription required for metabolic processes. In the lipid metabolism pathway RTR influences genes responsible for lipid uptake and storage linking its function to energy homeostasis.
- Associated diseases and disorders
RTR has significant associations with cancer and metabolic syndromes. Abnormal RTR function can disrupt gene regulation contributing to tumor growth and progression including breast and prostate cancers. In metabolic disorders RTR dysfunction correlates with insulin resistance and obesity. RTR's interaction with RXR becomes dysregulated in these conditions impacting signaling pathways and contributing to disease development.
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1 product image
SDS-PAGE - Recombinant Human RTR protein (ab114813)
12.5% SDS-PAGE Stained with Coomassie Blue
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Product protocols
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