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AB114813

Recombinant Human RTR protein (GST tag N-Terminus)

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Recombinant Human RTR protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 475 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

GCNF, NR6A1, Nuclear receptor subfamily 6 group A member 1, Germ cell nuclear factor, Retinoid receptor-related testis-specific receptor, hGCNF, RTR, hRTR

1 Images
SDS-PAGE - Recombinant Human RTR protein (GST tag N-Terminus) (AB114813)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RTR protein (GST tag N-Terminus) (AB114813)

12.5% SDS-PAGE Stained with Coomassie Blue

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

Q15406

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Recombinant protein</p>" } } }
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Sequence info

[{"sequence":"MERDEPPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTNDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSRSVELNGFMAFREQYMGMSVPPHYQYIPHLFSYSGHSPLLPQQARSLDPQSYSLIHQLLSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSVGKE","proteinLength":"Full Length","predictedMolecularWeight":"80.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":475,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q15406","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RTR also known as Retinoid Receptor is a transcription factor involved in regulating gene expression. Its molecular weight is approximately 55 kDa. RTR is expressed in various tissues with high expression levels found in liver brain and kidney. It binds to specific DNA sequences to control the transcription of genes related to cell differentiation and lipid metabolism. RTR belongs to the nuclear receptor superfamily indicating its role in responding to metabolic cues.
Biological function summary

RTR functions as an integral part of gene regulation networks by forming heterodimers with other nuclear receptors such as RXR (retinoid X receptor). This dimerization is necessary for binding to response elements in the DNA which modulates the transcription of target genes. The RTR-RXR complex plays an important role in cellular processes including development homeostasis and metabolism regulation impacting how cells respond to retinoic acid and other ligands.

Pathways

RTR plays significant roles in the retinoic acid signaling and lipid metabolism pathways. In the retinoic acid signaling pathway RTR regulates gene expression that is critical for embryonic development and cell differentiation. Through its interaction with other proteins like RXR RTR impacts the initiation of transcription required for metabolic processes. In the lipid metabolism pathway RTR influences genes responsible for lipid uptake and storage linking its function to energy homeostasis.

RTR has significant associations with cancer and metabolic syndromes. Abnormal RTR function can disrupt gene regulation contributing to tumor growth and progression including breast and prostate cancers. In metabolic disorders RTR dysfunction correlates with insulin resistance and obesity. RTR's interaction with RXR becomes dysregulated in these conditions impacting signaling pathways and contributing to disease development.
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Specifications

Form

Liquid

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General info

Function

Orphan nuclear receptor that binds to a response element containing the sequence 5'-TCAAGGTCA-3' (PubMed : 26769970). Acts as a regulator of embryonic stem cell pluripotency by mediating repression of POU5F1/OCT4 : binds to the DR0 element within the POU5F1/OCT4 promoter and inhibits POU5F1/OCT4 expression during embryonic stem cell differentiation (PubMed : 26769970). Involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).

Sequence similarities

Belongs to the nuclear hormone receptor family. NR6 subfamily.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Orphan nuclear receptor that binds to a response element containing the sequence 5'-TCAAGGTCA-3' (PubMed : 26769970). Acts as a regulator of embryonic stem cell pluripotency by mediating repression of POU5F1/OCT4 : binds to the DR0 element within the POU5F1/OCT4 promoter and inhibits POU5F1/OCT4 expression during embryonic stem cell differentiation (PubMed : 26769970). Involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).
See full target information NR6A1
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Product promise

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