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AB139198

Recombinant Human RWDD1 protein (His tag N-Terminus)

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Recombinant Human RWDD1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 243 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

DFRP2, CGI-24, PTD013, RWDD1, RWD domain-containing protein 1, DRG family-regulatory protein 2

1 Images
SDS-PAGE - Recombinant Human RWDD1 protein (His tag N-Terminus) (AB139198)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human RWDD1 protein (His tag N-Terminus) (AB139198)

15% SDS-PAGE analysis of 3 µg ab139198.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9H446

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMTDYGEEQRNELEALESIYPDSFTVLSENPPSFTITVTSEAGENDETVQTTLKFTYSEKYPDEAPLYEIFSQENLEDNDVSDILKLLALQAEENLGMVMIFTLVTAVQEKLNEIVDQIKTRREEEKKQKEKEAEEAEKQLFHGTPVTIENFLNWKAKFDAELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSDIQFLEDAGNNVEVDESLFQEMDDLELEDDEDDPDYNPADPESDSAD","proteinLength":"Full Length","predictedMolecularWeight":"30.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":243,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H446","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RWDD1 also known as RWD domain-containing protein 1 is a protein with a molecular mass of approximately 12 kDa. This protein is expressed in various tissues including the brain liver and kidney. Mechanically RWDD1 interacts with other proteins through its RWD domain which is a conserved region facilitating protein-protein interactions. This domain helps RWDD1 participate in cellular processes by serving as a regulatory subunit in protein complexes.
Biological function summary

RWDD1 influences cellular activities due to its role in modulating protein degradation pathways. It is part of protein complexes that are involved in tagging proteins for degradation. This modulation affects many cellular processes such as cell cycle control and stress responses. The protein may work closely with proteasomal subunit proteins suggesting it has a specific function in maintaining cellular protein homeostasis.

Pathways

RWDD1 is actively involved in the ubiquitin-proteasome system which is a significant pathway for protein degradation. It interacts with proteins involved in ubiquitination processes which tag proteins for breakdown. Additionally RWDD1 plays a role in cellular response pathways to oxidative stress through associations with proteins like Nrf2 a well-known regulator of the antioxidant response.

Dysregulation of RWDD1 may link to cancer and neurodegenerative diseases. Abnormal RWDD1 function can lead to impaired protein degradation contributing to the accumulation of damaged or misfolded proteins a common feature in these conditions. Associations with proteins such as p53 in cancer and links to tau proteins in Alzheimer’s disease highlight its potential involvement in disease mechanisms.
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Specifications

Form

Liquid

Additional notes

ab139198 is purified using conventional chromatography techniques.

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General info

Function

Protects DRG2 from proteolytic degradation.

Sequence similarities

Belongs to the RWDD1/GIR2 family.

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Product protocols

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Target data

Protects DRG2 from proteolytic degradation.
See full target information RWDD1
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Complementary Products

Primary Antibodies

AB181994

Anti-RWDD1 antibody [EPR13715(B)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-RWDD1 antibody [EPR13715(B)] (AB181994)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB137383

Anti-Carma 3 antibody

Western blot - Anti-Carma 3 antibody (AB137383)

  • 0
  • 0
Primary Antibodies

AB220962

Anti-C11orf84 antibody

Immunocytochemistry/ Immunofluorescence - Anti-C11orf84 antibody (AB220962)

  • 0
  • 0

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