Recombinant Human RXRG protein is a Human Full Length protein, in the 1 to 463 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M Y G N Y S H F M K F P A G Y G G S P G H T G S T S M S P S A A L S T G K P M D S H P S Y T D T P V S A P R T L S A V G T P L N A L G S P Y R V I T S A M G P P S G A L A A P P G I N L V A P P S S Q L N V V N S V S S S E D I K P L P G L P G I G N M N Y P S T S P G S L V K H I C A I C G D R S S G K H Y G V Y S C E G C K G F F K R T I R K D L I Y T C R D N K D C L I D K R Q R N R C Q Y C R Y Q K C L V M G M K R E A V Q E E R Q R S R E R A E S E A E C A T S G H E D M P V E R I L E A E L A V E P K T E S Y G D M N M E N S T N D P V T N I C H A A D K Q L F T L V E W A K R I P H F S D L T L E D Q V I L L R A G W N E L L I A S F S H R S V S V Q D G I L L A T G L H V H R S S A H S A G V G S I F D R V L T E L V S K M K D M Q M D K S E L G C L R A I V L F N P D A K G L S N P S E V E T L R E K V Y A T L E A Y T K Q K Y P E Q P G R F A K L L L R L P A L R S I G L K C L E H L F F F K L I G D T P I D T F L M E M L E T P L Q I T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Alternative names
NR2B3, RXRG, Retinoic acid receptor RXR-gamma, Nuclear receptor subfamily 2 group B member 3, Retinoid X receptor gamma
Recommended products
Recombinant Human RXRG protein is a Human Full Length protein, in the 1 to 463 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P48443-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
- M Y G N Y S H F M K F P A G Y G G S P G H T G S T S M S P S A A L S T G K P M D S H P S Y T D T P V S A P R T L S A V G T P L N A L G S P Y R V I T S A M G P P S G A L A A P P G I N L V A P P S S Q L N V V N S V S S S E D I K P L P G L P G I G N M N Y P S T S P G S L V K H I C A I C G D R S S G K H Y G V Y S C E G C K G F F K R T I R K D L I Y T C R D N K D C L I D K R Q R N R C Q Y C R Y Q K C L V M G M K R E A V Q E E R Q R S R E R A E S E A E C A T S G H E D M P V E R I L E A E L A V E P K T E S Y G D M N M E N S T N D P V T N I C H A A D K Q L F T L V E W A K R I P H F S D L T L E D Q V I L L R A G W N E L L I A S F S H R S V S V Q D G I L L A T G L H V H R S S A H S A G V G S I F D R V L T E L V S K M K D M Q M D K S E L G C L R A I V L F N P D A K G L S N P S E V E T L R E K V Y A T L E A Y T K Q K Y P E Q P G R F A K L L L R L P A L R S I G L K C L E H L F F F K L I G D T P I D T F L M E M L E T P L Q I T
- Accession
- P48443
- Protein length
- Full Length
- Predicted molecular weight
- 77 kDa
- Amino acids
- 1 to 463
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
- Sequence similarities
Belongs to the nuclear hormone receptor family. NR2 subfamily.
- Post-translational modifications
Acetylated by EP300.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as Retinoid X Receptor gamma.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
RXRG also known as retinoid X receptor gamma is a nuclear receptor protein weighing approximately 55 kDa. It binds retinoic acids and mediates their effects in the cell. RXRG can form homodimers or heterodimers with other nuclear receptors. The protein's expression occurs mainly in the brain muscles and the spleen. As a transcription factor it regulates gene expression by binding to specific DNA sequences influencing various cellular processes.
- Biological function summary
RXRG acts as a transcriptional regulator in the retinoid signaling pathway. It forms part of a heterodimer complex with receptors such as PPARs (peroxisome proliferator-activated receptors) and RXR α and β subunits. These complexes control genes involved in cell differentiation proliferation and apoptosis. Through RXRG cells can transduce external retinoid signals into specific gene expression responses impacting development and metabolic processes.
- Pathways
RXRG integrates into significant signaling cascades including the retinoic acid signaling pathway and the adipogenesis pathway. It often partners with other nuclear receptors like RARs (retinoic acid receptors) and PPARs to mediate these pathways. For instance in the adipogenesis pathway RXRG's interaction with PPARγ regulates adipocyte differentiation and lipid metabolism. These pathways link to extensive roles in development and metabolic regulation.
- Associated diseases and disorders
RXRG plays a role in conditions such as obesity and certain types of cancer. In obesity the interaction between RXRG and PPARγ influences fat cell formation and energy balance. Additionally dysregulation of RXRG expression associates with cancers where it interacts with proteins like RXRα to alter cell proliferation and apoptosis. Understanding these associations highlights RXRG's importance in therapeutic research and potential drug targets.
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1 product image
SDS-PAGE - Recombinant Human RXRG protein (ab114438)
ab114438 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.
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