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AB114438

Recombinant Human RXRG protein (GST tag N-Terminus)

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Recombinant Human RXRG protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 463 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

NR2B3, RXRG, Retinoic acid receptor RXR-gamma, Nuclear receptor subfamily 2 group B member 3, Retinoid X receptor gamma

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SDS-PAGE - Recombinant Human RXRG protein (GST tag N-Terminus) (AB114438)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RXRG protein (GST tag N-Terminus) (AB114438)

ab114438 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA, SDS-PAGE

applications

Biologically active

No

Accession

P48443

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB53162

Anti-RXRG antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RXRG antibody (AB53162)

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  • 3
Cell Lines & Lysates

AB94313

RXRG overexpression 293T lysate (whole cell)

Western blot - RXRG overexpression 293T lysate (whole cell) (AB94313)

  • 0
  • 0
Proteins & Peptides

AB114584

Recombinant Human DPD protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human DPD protein (GST tag N-Terminus) (AB114584)

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  • 0
Proteins & Peptides

AB219276

Recombinant human PGAM2 protein (Active) (His tag N-Terminus)

SDS-PAGE - Recombinant human PGAM2 protein (Active) (His tag N-Terminus) (AB219276)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Retinoid X Receptor gamma.
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Sequence info

[{"sequence":"MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT","proteinLength":"Full Length","predictedMolecularWeight":"77 kDa","actualMolecularWeight":null,"aminoAcidEnd":463,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P48443","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RXRG also known as retinoid X receptor gamma is a nuclear receptor protein weighing approximately 55 kDa. It binds retinoic acids and mediates their effects in the cell. RXRG can form homodimers or heterodimers with other nuclear receptors. The protein's expression occurs mainly in the brain muscles and the spleen. As a transcription factor it regulates gene expression by binding to specific DNA sequences influencing various cellular processes.
Biological function summary

RXRG acts as a transcriptional regulator in the retinoid signaling pathway. It forms part of a heterodimer complex with receptors such as PPARs (peroxisome proliferator-activated receptors) and RXR α and β subunits. These complexes control genes involved in cell differentiation proliferation and apoptosis. Through RXRG cells can transduce external retinoid signals into specific gene expression responses impacting development and metabolic processes.

Pathways

RXRG integrates into significant signaling cascades including the retinoic acid signaling pathway and the adipogenesis pathway. It often partners with other nuclear receptors like RARs (retinoic acid receptors) and PPARs to mediate these pathways. For instance in the adipogenesis pathway RXRG's interaction with PPARγ regulates adipocyte differentiation and lipid metabolism. These pathways link to extensive roles in development and metabolic regulation.

RXRG plays a role in conditions such as obesity and certain types of cancer. In obesity the interaction between RXRG and PPARγ influences fat cell formation and energy balance. Additionally dysregulation of RXRG expression associates with cancers where it interacts with proteins like RXRα to alter cell proliferation and apoptosis. Understanding these associations highlights RXRG's importance in therapeutic research and potential drug targets.
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Specifications

Form

Liquid

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General info

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

Sequence similarities

Belongs to the nuclear hormone receptor family. NR2 subfamily.

Post-translational modifications

Acetylated by EP300.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
See full target information RXRG
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Product promise

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