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Recombinant Human S100 Calcium Binding Protein A13/S100A13 is a Human Full Length protein, in the 1 to 98 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.

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Images

SDS-PAGE - Recombinant Human S100 Calcium Binding Protein A13/S100A13 (AB105573), expandable thumbnail

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, MS

Biologically active

No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M A A E P L T E L E E S I E T V V T T F F T F A R Q E G R K D S L S V N E F K E L V T Q Q L P H L L K D V G S L D E K M K S L D V N Q D S E L K F N E Y W R L I G E L A K E I R K K K D L K I R K K

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

MS

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).

Alternative names

Recommended products

Recombinant Human S100 Calcium Binding Protein A13/S100A13 is a Human Full Length protein, in the 1 to 98 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE, MS

Accession
Q99584-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M A A E P L T E L E E S I E T V V T T F F T F A R Q E G R K D S L S V N E F K E L V T Q Q L P H L L K D V G S L D E K M K S L D V N Q D S E L K F N E Y W R L I G E L A K E I R K K K D L K I R K K

Accession

Q99584

Protein length

Full Length

Predicted molecular weight

13.6 kDa

Amino acids

1 to 98

Nature

Recombinant

Tags

His tag N-Terminus

Specifications

Form

Liquid

Additional notes

ab105573 was purified using conventional chromatography.

General info

Function

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).

Sequence similarities

Belongs to the S-100 family.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

This product was previously labelled as S100 Calcium Binding Protein A13

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

S100 Calcium Binding Protein A13 also known as S100A13 is a member of the S100 protein family and displays calcium-binding abilities usually binding two calcium ions. This small protein has a molecular mass of approximately 11 kDa. S100A13 is expressed in a variety of tissues including the heart brain and skeletal muscle. Its expression can be altered in different cellular conditions suggesting an adaptive role in diverse physiological contexts.

Biological function summary

S100A13 influences several cellular processes related to growth and differentiation. This protein facilitates secretion of fibroblast growth factor 1 (FGF1) and interleukin-1 alpha (IL-1α) through a non-classical pathway. S100A13 does not function alone; it engages in complexes with other proteins to execute its roles. It often works together with S100A6 and calcyclin-binding protein in these secretory pathways.

Pathways

S100A13 participates in the regulation of angiogenesis and inflammation. It is involved in the FGF signal transduction pathway by affecting the externalization of FGF1 an important player in angiogenesis. Additionally S100A13 contributes to inflammation-related processes. Its activity is linked to proteins such as p53 and FGF1 integrating it into wider cellular systems.

Associated diseases and disorders

S100A13 is implicated in cancer and chronic inflammatory conditions. Overexpression of S100A13 has links to tumor progression and aggressiveness suggesting a role in cancer. In chronic inflammation S100A13 associates with increased levels of inflammatory cytokines. It connects to proteins like FGF1 and IL-1α in these contexts linking it with pathophysiological mechanisms that underlie these conditions.

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1 product image

  • SDS-PAGE - Recombinant Human S100 Calcium Binding Protein A13/S100A13 (ab105573), expandable thumbnail

    SDS-PAGE - Recombinant Human S100 Calcium Binding Protein A13/S100A13 (ab105573)

    15% SDS-PAGE analysis of ab105573 (3ug)

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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