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AB105573

Recombinant Human S100 Calcium Binding Protein A13/S100A13

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Recombinant Human S100 Calcium Binding Protein A13/S100A13 is a Human Full Length protein, in the 1 to 98 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Protein S100-A13, S100 calcium-binding protein A13, S100A13

1 Images
SDS-PAGE - Recombinant Human S100 Calcium Binding Protein A13/S100A13 (AB105573)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human S100 Calcium Binding Protein A13/S100A13 (AB105573)

15% SDS-PAGE analysis of ab105573 (3ug)

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q99584

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as S100 Calcium Binding Protein A13
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAAEPLTELEESIETVVTTFFTFARQEGRKDSLSVNEFKELVTQQLPHLLKDVGSLDEKMKSLDVNQDSELKFNEYWRLIGELAKEIRKKKDLKIRKK","proteinLength":"Full Length","predictedMolecularWeight":"13.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":98,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99584","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

S100 Calcium Binding Protein A13 also known as S100A13 is a member of the S100 protein family and displays calcium-binding abilities usually binding two calcium ions. This small protein has a molecular mass of approximately 11 kDa. S100A13 is expressed in a variety of tissues including the heart brain and skeletal muscle. Its expression can be altered in different cellular conditions suggesting an adaptive role in diverse physiological contexts.
Biological function summary

S100A13 influences several cellular processes related to growth and differentiation. This protein facilitates secretion of fibroblast growth factor 1 (FGF1) and interleukin-1 alpha (IL-1α) through a non-classical pathway. S100A13 does not function alone; it engages in complexes with other proteins to execute its roles. It often works together with S100A6 and calcyclin-binding protein in these secretory pathways.

Pathways

S100A13 participates in the regulation of angiogenesis and inflammation. It is involved in the FGF signal transduction pathway by affecting the externalization of FGF1 an important player in angiogenesis. Additionally S100A13 contributes to inflammation-related processes. Its activity is linked to proteins such as p53 and FGF1 integrating it into wider cellular systems.

S100A13 is implicated in cancer and chronic inflammatory conditions. Overexpression of S100A13 has links to tumor progression and aggressiveness suggesting a role in cancer. In chronic inflammation S100A13 associates with increased levels of inflammatory cytokines. It connects to proteins like FGF1 and IL-1α in these contexts linking it with pathophysiological mechanisms that underlie these conditions.
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Specifications

Form

Liquid

Additional notes

ab105573 was purified using conventional chromatography.

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General info

Function

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).

Sequence similarities

Belongs to the S-100 family.

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Product protocols

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Target data

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).
See full target information Protein S100-A13
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Complementary Products

Primary Antibodies

AB109252

Anti-S100 Calcium Binding Protein A13/S100A13 antibody [EPR4510]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S100 Calcium Binding Protein A13/S100A13 antibody [EPR4510] (AB109252)

  • 0
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Proteins & Peptides

AB130025

Recombinant Mouse S100A3 protein

SDS-PAGE - Recombinant Mouse S100A3 protein (AB130025)

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  • 0
Primary Antibodies

AB90716

Anti-Prosurfactant Protein C antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-Prosurfactant Protein C antibody (AB90716)

  • 4
  • 12
Primary Antibodies

AB271345

Anti-Surfactant Protein B antibody [RM370]

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Surfactant Protein B antibody [RM370] (AB271345)

  • 0
  • 0

Product promise

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