Recombinant Human S100A3 protein is a Human Full Length protein, in the 1 to 101 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
SDS-PAGE, ELISA, WB
- Biologically active
No
Amino acid sequence
M A R P L E Q A V A A I V C T F Q E Y A G R C G D K Y K L C Q A E L K E L L Q K E L A T W T P T E F R E C D Y N K F M S V L D T N K D C E V D F V E Y V R S L A C L C L Y C H E Y F K D C P S E P P C S Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes Recombinant protein. |
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Target data
Function
Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.
Alternative names
S100E, S100A3, Protein S100-A3, Protein S-100E, S100 calcium-binding protein A3
Recommended products
Recombinant Human S100A3 protein is a Human Full Length protein, in the 1 to 101 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
SDS-PAGE, ELISA, WB
- Biologically active
No
- Accession
- P33764-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
M A R P L E Q A V A A I V C T F Q E Y A G R C G D K Y K L C Q A E L K E L L Q K E L A T W T P T E F R E C D Y N K F M S V L D T N K D C E V D F V E Y V R S L A C L C L Y C H E Y F K D C P S E P P C S Q
- Accession
- P33764
- Protein length
Full Length
- Predicted molecular weight
36.74 kDa
- Amino acids
1 to 101
- Nature
Recombinant
- Tags
GST tag N-Terminus
Specifications
- Form
Liquid
General info
- Function
Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.
- Sequence similarities
Belongs to the S-100 family.
- Post-translational modifications
More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization.
Storage
- Shipped at conditions
Dry Ice
- Appropriate short-term storage conditions
-80°C
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
S100A3 also known as protein S100-A3 is a member of the S100 protein family characterized by calcium-binding motifs specifically the EF-hand motif. This protein has a molecular mass of approximately 11 kDa. S100A3 expresses primarily in tissues such as hair follicles and is particularly abundant in the filiform region of human hair cuticles. Its presence is significant in cellular compartments where it interacts with zinc and calcium ions suggesting a role in ion homeostasis and regulation.
- Biological function summary
S100A3 participates in various cellular functions including cytoskeletal dynamics cell motility and differentiation. This protein does not form part of a larger complex but interacts closely with other proteins involved in maintaining cellular architecture and intracellular signaling. Its function involves modulating enzymatic activities and facilitating structural stability. The zinc-binding properties enhance the protein's ability to participate in structural organization and signaling pathways.
- Pathways
S100A3 interacts with several signaling and regulatory pathways integral to cellular structure and function. It plays a role in the calcium signaling pathway influencing processes mediated by calcium ions including muscle contraction and neurotransmitter release. Additionally S100A3 participates in pathways related to cell differentiation through interactions with cytoskeletal proteins contributing to epithelial and hair follicle cell differentiation and growth.
- Associated diseases and disorders
S100A3 has been linked to conditions such as breast cancer and melanoma. Its interaction with calcium-binding proteins may affect tumor initiation and progression. In breast cancer S100A3 expression levels could correlate with tumor invasiveness where it might work together with proteins like S100A4. In melanoma variations in S100A3 expression could contribute to cell migration and invasion indicating its potential as a biomarker for disease progression and therapeutic targeting.
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1 product image
SDS-PAGE - Recombinant Human S100A3 protein (ab116969)
12.5% SDS-PAGE showing ab116969 at approximately 36.74kDa.
Stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
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