Recombinant Human S100Z protein is a Human Full Length protein, in the 1 to 99 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M P T Q L E M A M D T M I R I F H R Y S G K E R K R F K L S K G E L K L L L Q R E L T E F L S C Q K E T Q L V D K I V Q D L D A N K D N E V D F N E F V V M V A A L T V A C N D Y F V E Q L K K K G K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
Protein S100-Z, S100 calcium-binding protein Z, S100Z
Recommended products
Recombinant Human S100Z protein is a Human Full Length protein, in the 1 to 99 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q8WXG8-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M P T Q L E M A M D T M I R I F H R Y S G K E R K R F K L S K G E L K L L L Q R E L T E F L S C Q K E T Q L V D K I V Q D L D A N K D N E V D F N E F V V M V A A L T V A C N D Y F V E Q L K K K G K
- Accession
- Q8WXG8
- Protein length
- Full Length
- Predicted molecular weight
- 13.7 kDa
- Amino acids
- 1 to 99
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab97408 is purified using conventional chromatography techniques.
General info
- Sequence similarities
Belongs to the S-100 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
S100Z also known as S100 calcium-binding protein Z or S100-G is part of the S100 protein family characterized by two EF-hand calcium-binding motifs. The protein has a molecular weight of approximately 10 kDa. It is mainly expressed in the liver heart and kidney tissues. S100Z interacts with calcium ions which subsequently influences its conformation and activity. Its expression patterns suggest a role in tissue-specific functions where calcium ion concentration is critical.
- Biological function summary
S100Z affects cellular processes related to calcium ion-dependent signal transduction. It is suggested to modify proteins or pathways involved in intracellular calcium message systems. S100Z may participate in protein-protein interactions that regulate cellular functions like proliferation or differentiation. While direct evidence of S100Z forming a part of larger protein complexes is limited its modulatory capabilities imply its significance in complex cellular machinery involving calcium ions.
- Pathways
Research suggests that S100Z functions within the MAPK and NF-kB signaling pathways. These pathways regulate essential cellular responses such as inflammation and stress reactions. S100Z likely interacts with other proteins such as the p65 subunit of NF-kB and ERK1/2 kinases in the MAPK pathway to modulate reactions and outcomes related to these signals. Its role in these pathways may affect cellular fate during adverse conditions.
- Associated diseases and disorders
Research links S100Z to conditions such as cancer and inflammatory diseases. Alterations in S100Z expression or function can influence cancer cell proliferation implicating it as a contributor to tumorigenesis. Studies propose that S100Z interactions with proteins like NF-kB and ERK1 might mediate inflammatory responses leading to disorders where these pathways are dysregulated. These links suggest that S100Z could serve as a potential biomarker or therapeutic target for related diseases.
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1 product image
SDS-PAGE - Recombinant Human S100Z protein (ab97408)
15% SDS-PAGE showing ab97408 at approximately 13.7kDa (3μg).
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