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AB181918

Recombinant Human SAMSN1 protein

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Recombinant Human SAMSN1 protein is a Human Full Length protein, in the 1 to 373 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

HACS1, SAMSN1, SAM domain-containing protein SAMSN-1, Hematopoietic adaptor containing SH3 and SAM domains 1, Nash1, SH3-SAM adaptor protein

1 Images
SDS-PAGE - Recombinant Human SAMSN1 protein (AB181918)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SAMSN1 protein (AB181918)

15% SDS-PAGE analysis of ab181918 (3μg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9NSI8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLKRKPSNVSEKEKHQKPKRSSSFGNFDRFRNNSLSKPDDSTEAHEGDPTNGSGEQSKTSNNGGGLGKKMRAISWTMKKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKVSLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEEEAAPKKIKANRRSNSKKSKTLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIENPDDRRRLLSAAENFLEEEIIQEQENEPEPLSLSSDISLNKSQLDDCPRDSGCYISSGNSDNGKEDLESENLSDMVHKIIITEPSD","proteinLength":"Full Length","predictedMolecularWeight":"44.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":373,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NSI8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SAMSN1 also known as HACS1 or SLY2 is a protein that functions primarily as an adapter protein involved in signal transduction. It has a mass of approximately 46 kDa. This protein is expressed in several tissues with high levels found in lymphoid organs like the spleen and peripheral blood leukocytes. SAMSN1 modulates protein-protein interactions through its SAM (sterile alpha motif) domain and a SH3 (Src homology 3) domain enabling it to interact with other critical proteins within cells.
Biological function summary

The function of SAMSN1 is essential in the immune response and cell signaling processes. It is part of signaling complexes that regulate immune cell function particularly B cells and T cells. By binding to other signaling proteins SAMSN1 can influence pathways that control cell growth differentiation and survival. This protein also participates in modulating transcription factors that are critical for immune cell maturation and function.

Pathways

SAMSN1 is significantly involved in the B-cell receptor signaling and the PI3K/Akt pathway. Through these pathways SAMSN1 affects the regulation of signal transduction cascades involved in cell proliferation and survival. It interacts with proteins such as PI3K and Akt which are significant in transducing signals that impact cellular responses to external stimuli.

SAMSN1 has been linked to autoimmune diseases and cancer. Altered expression of this protein can contribute to the development of conditions such as systemic lupus erythematosus and certain lymphomas. Interactions between SAMSN1 and proteins like BCR (B-cell receptor) play a role in the pathology of these disorders where dysregulation in signaling pathways may lead to the abnormal proliferation of immune cells or their improper functioning.
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Specifications

Form

Liquid

Additional notes

ab181918 was purified by using conventional chromatography.

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General info

Function

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).

Subcellular localisation

Nucleus

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Product protocols

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Target data

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).
See full target information SAMSN1
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