Recombinant Human SAP18 protein
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Recombinant Human SAP18 protein is a Human Full Length protein, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
GIG38, SAP18, Histone deacetylase complex subunit SAP18, 18 kDa Sin3-associated polypeptide, 2HOR0202, Cell growth-inhibiting gene 38 protein, Sin3-associated polypeptide p18
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human SAP18 protein (AB86702)
15% SDS-PAGE showing ab86702 at approximately 19.7kDa (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Proteins such as SAP18 influence essential processes by serving as a component of the Sin3A/histone deacetylase (HDAC) complexes. These complexes facilitate transcriptional repression by removing acetyl groups from histone proteins which leads to chromatin condensation and reduced gene activity. SAP18 as part of these complexes aids in regulating genes involved in cell differentiation apoptosis and development. Its role in these processes highlights its importance in maintaining cellular functions and homeostasis.
Pathways
The role of SAP18 in gene expression regulation supports its involvement in key pathways such as cell cycle control and signal transduction. In the context of the cell cycle pathway SAP18 and its complexes work closely with other regulatory proteins like Rb and E2F to ensure proper cell cycle progression by modulating transcription of cycle-dependent genes. In signal transduction pathways SAP18 has the capacity to interact with proteins like HDAC1 influencing the downstream signaling that impacts cell fate decisions.
Specifications
Form
Liquid
Additional notes
ab86702 is purified using conventional chromatography techniques.Endotoxin level: < 1.0 EU per 1 μg of protein (determined by LAL method).
General info
Function
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
Sequence similarities
Belongs to the SAP18 family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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