Recombinant Human SAP97 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The function of SAP97 is closely linked to synaptic plasticity and signal transduction. This protein forms part of larger protein complexes that include ion channels and receptors helping regulate the transmission of signals between neurons. In the brain SAP97 facilitates the clustering of neurotransmitter receptors at synapses including AMPA receptors which are vital for excitatory synaptic transmission. Its role extends to modulating the structural organization and functional regulation of these protein complexes at synaptic junctions.

Pathways

SAP97 is involved in key signaling processes particularly the glutamatergic synapse pathway where it influences the trafficking and surface expression of glutamate receptors. It interacts with other MAGUK family members like PSD-95 to regulate the assembly of the postsynaptic density. This protein also plays a role in the cardiac signaling cascade particularly in interactions involving potassium channels impacting the cardiac action potential.