Recombinant Human SARA protein is a Human Fragment protein, in the 1013 to 1280 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
MADHIP, SARA, SMADIP, ZFYVE9, Zinc finger FYVE domain-containing protein 9, Mothers against decapentaplegic homolog-interacting protein, Novel serine protease, Receptor activation anchor, Smad anchor for receptor activation, Madh-interacting protein, NSP, hSARA
Recombinant Human SARA protein is a Human Fragment protein, in the 1013 to 1280 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Constituents: 0.58% Sodium chloride, 0.32% Tris HCl
Purified via His tag
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
SARA also known as Smad anchor for receptor activation plays an important mechanical role in cellular signaling. It functions by binding to phosphorylated receptor-regulated Smad proteins (R-Smads) and facilitating their movement and accumulation in the nucleus. SARA has a molecular mass of approximately 150 kDa and is prominently expressed in a variety of tissues including the brain liver and kidney indicating a widespread functional role in physiological processes.
SARA engages in interactions with several signaling molecules in the cell. It acts as a scaffolding protein that forms part of a complex with the Smad proteins assisting in the regulation of transforming growth factor-beta (TGF-β) signaling. By serving as a critical link between membranes and the cytoplasm it ensures the accurate transmission of signals necessary for cellular responses. Its location and function highlight its vital role in maintaining cellular homeostasis.
SARA plays an important role in TGF-β and bone morphogenetic protein (BMP) signaling pathways. These pathways are essential for regulating cellular processes such as proliferation differentiation and apoptosis. SARA interacts with Smad2 Smad3 and Smad7 which are key components of these pathways. Through these interactions SARA helps mediate the transduction of signals that guide complex cellular activities and responses linking external signals to gene expression inside the nucleus.
Research has linked SARA to cancer and fibrotic diseases. Its role in TGF-β signaling suggests that alterations in SARA expression or function can contribute to tumor progression and metastatic processes. Additionally in fibrotic diseases where excess tissue scarring occurs the modulation of the pathway by proteins like Smad2 and Smad3 with SARA's involvement can result in aberrant tissue responses. Understanding SARA's involvement in these conditions may offer potential therapeutic insights.
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