Recombinant Human SBEM protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Small breast epithelial mucin (SBEM) also known as HME1 is a glycoprotein with a mass of approximately 90 kDa. SBEM is predominantly expressed in breast tissue but also appears in salivary glands and lungs. The protein's expression is limited to mammary epithelial cells indicating a tissue-specific role. As a mucin SBEM is heavily glycosylated which plays a role in its mechanical function as it may be involved in cell adhesion and signal transduction.

Biological function summary

SBEM functions in epithelial cell activity potentially influencing cell communication and structural organization. While not part of a large complex SBEM interacts with other proteins at the cell surface impacting cellular signaling pathways. Its role in facilitating interactions within the epithelial cell layer suggests a contribution to maintaining the integrity and function of epithelial tissues.

Pathways

SBEM interacts with at least two key biological signaling pathways including the epidermal growth factor receptor (EGFR) pathway and the mucin biosynthesis pathway. In the EGFR pathway SBEM may relate to proteins involved in cell division and differentiation such as epidermal growth factor receptor itself. Through mucin biosynthesis the activity of SBEM aligns with other mucins like MUC1 which also regulate cell surface interactions and signaling.

SBEM shows a notable connection to breast cancer due to its expression pattern restricted to breast epithelial cells. The protein has potential as a biomarker for detecting and monitoring this cancer type. Its expression correlates with tumor progression and differentiation status. Additionally chronic lung diseases show a linkage to SBEM's dysregulation possibly through interactions with other epithelial proteins like MUC5B highlighting its importance in epithelial homeostasis and disease pathology.