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AB204137

Recombinant human SBK1 protein

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Recombinant human SBK1 protein is a Human Full Length protein, in the 1 to 424 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.

View Alternative Names

Serine/threonine-protein kinase SBK1, SH3 domain-binding kinase 1, SBK1

4 Images
Functional Studies - Recombinant human SBK1 protein (AB204137)
  • FuncS

Supplier Data

Functional Studies - Recombinant human SBK1 protein (AB204137)

Sample Kinase Activity Plot showing ab204137. The specific activity of SBK1 was determined to be 20 nmol /min/mg.

Functional Studies - Recombinant human SBK1 protein (AB204137)
  • FuncS

Unknown

Functional Studies - Recombinant human SBK1 protein (AB204137)

The specific activity of SBK1 (ab204137) was determined to be 17 nmol/min/mg as per activity assay protocol

SDS-PAGE - Recombinant human SBK1 protein (AB204137)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human SBK1 protein (AB204137)

SDS PAGE analysis of ab204137

SDS-PAGE - Recombinant human SBK1 protein (AB204137)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human SBK1 protein (AB204137)

SDS-PAGE showing ab204137.

Key facts

Purity

>90% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

The specific activity of ab204137 was determined to be 20 nmol /min/mg.

Accession

Q52WX2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Complementary Products

Primary Antibodies

AB32515

Anti-CREB antibody [E306]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CREB antibody [E306] (AB32515)

  • 5
  • 4
Primary Antibodies

AB137565

Anti-CREB3L1/OASIS antibody

Western blot - Anti-CREB3L1/OASIS antibody (AB137565)

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Primary Antibodies

AB75991

Anti-PKA alpha/beta/gamma (catalytic subunit) (phospho T197) antibody [EP2606Y]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PKA alpha/beta/gamma (catalytic subunit) (phospho T197) antibody [EP2606Y] (AB75991)

  • 5
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Primary Antibodies

AB32390

Anti-PKA R2/PKR2 (phospho S99) antibody [E151]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PKA R2/PKR2 (phospho S99) antibody [E151] (AB32390)

  • 4
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

ab204874 (PKI-alpha peptide) can be utilized as a substrate for assessing kinase activity
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Sequence info

[{"sequence":"MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAIEICV","proteinLength":"Full Length","predictedMolecularWeight":"69 kDa","actualMolecularWeight":null,"aminoAcidEnd":424,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q52WX2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SBK1 also known as SH3 domain binding kinase 1 is a serine/threonine protein kinase. It measures approximately 110 kDa in mass. SBK1 expresses in various tissues including the brain and testis suggesting its involvement in multiple physiological processes. The kinase activity of SBK1 participates in phosphorylating target proteins influencing cellular functions. Researchers often study SBK1 to understand the regulation of signaling pathways in the nervous system.
Biological function summary

SBK1 plays important roles in the regulation of neuronal development and synaptic function. It often associates with protein complexes that guide cellular signaling and differentiation. The kinase activity impacts the structure and function of synapses affecting how neurons connect and communicate. By interacting with other kinases and signaling molecules SBK1 contributes to the development function and maintenance of neuronal circuits.

Pathways

SBK1 integrates into vital signaling networks including the MAPK and PI3K-Akt pathways. These pathways manage diverse cellular responses such as growth survival and differentiation. SBK1 interacts with other pathway members such as ERK1/2 in the MAPK pathway coordinating responses that control cell fate and function. By modulating these pathways SBK1 impacts key cellular processes providing insights into its broader physiological roles.

SBK1 relates to neurological conditions and certain cancers. The dysregulation of SBK1 can contribute to disorders like schizophrenia where its altered signaling affects brain function and structure. In cancer overactive SBK1-driven pathways influence cell proliferation and survival contributing to tumor development. Through these conditions SBK1 intersects with proteins like AKT indicating its significant impact in disease progression and as a potential therapeutic target.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

May be involved in signal-transduction pathways related to the control of brain development.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

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Product protocols

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Target data

May be involved in signal-transduction pathways related to the control of brain development.
See full target information SBK1
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Product promise

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