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AB161580

Recombinant Human SCC112 protein (GST tag N-Terminus)

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Recombinant Human SCC112 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 333 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA0648, PDS5, PIG54, PDS5A, Sister chromatid cohesion protein PDS5 homolog A, Cell proliferation-inducing gene 54 protein, Sister chromatid cohesion protein 112, SCC-112

1 Images
SDS-PAGE - Recombinant Human SCC112 protein (GST tag N-Terminus) (AB161580)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SCC112 protein (GST tag N-Terminus) (AB161580)

ab161580 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q29RF7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Recombinant Human CCP1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human CCP1 protein (GST tag N-Terminus) (AB161588)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDESKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPAGVLGAVNKPLSATGRKPYVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSENEENPVRIISVTPVKNIDPVKNKEINSDQATQGNISSDRGKKRTVTAAGAENIQQKTDEKVDESGPPAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQDLAKKAAPAERQIDLQR","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":333,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q29RF7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCC112 also known as LAP1B is a protein involved in cellular structure and function processes. It has a molecular weight of approximately 75 kDa. SCC112 is expressed in various tissues including liver kidney and muscle. The protein is localized mainly to the inner nuclear membrane where it plays roles in maintaining nuclear structure and function. This localization position allows SCC112 to interact with a range of other nuclear proteins showing its involvement in broader cellular processes.
Biological function summary

The role of SCC112 is linked to its ability to regulate nuclear architecture and chromatin organization. It is part of the nuclear lamina-associated polypeptide family and is involved in complex formations with proteins responsible for maintaining nuclear stability. SCC112 influences the dynamics of chromatin interactions which impacts gene expression. Through these complex formations SCC112 helps in organizing the nuclear architecture which has downstream effects on various cellular activities.

Pathways

SCC112 acts within the nuclear envelope dynamics and chromatin organization pathways. It closely interacts with lamin proteins such as LMNA and LMNB1 which are essential for nuclear stability. These interactions facilitate the cohesion of nuclear structures and are necessary for appropriate chromatin organization. The involvement of SCC112 in these pathways suggests a broad influence on cellular replication and gene regulation. The precise regulation of chromatin architecture by SCC112 plays a significant part in cellular division processes and the maintenance of cellular integrity.

SCC112 has been associated with muscular dystrophy and certain types of cancer. Alterations in SCC112 expression levels can impact the balance of nuclear stability contributing to diseases such as Emery-Dreifuss muscular dystrophy where LMNA mutations are prevalent. Also abnormalities in SCC112 have been noted in certain cancer types suggesting a possible role in tumor progression. The connection with these diseases highlights the significant influence of SCC112 on nuclear integrity and cellular health.
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Specifications

Form

Liquid

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General info

Function

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Sequence similarities

Belongs to the PDS5 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
See full target information PDS5A
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