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AB134520

Recombinant Human SCDGFB/PDGF-D protein (denatured)

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Recombinant Human SCDGFB/PDGF-D protein (denatured) is a Human Fragment protein, in the 250 to 370 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

IEGF, SCDGFB, MSTP036, UNQ1899/PRO4345, PDGFD, Platelet-derived growth factor D, PDGF-D, Iris-expressed growth factor, Spinal cord-derived growth factor B, SCDGF-B

2 Images
SDS-PAGE - Recombinant Human SCDGFB/PDGF-D protein (denatured) (AB134520)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human SCDGFB/PDGF-D protein (denatured) (AB134520)

15% SDS-PAGE analysis of ab134520 (3μg)

SDS-PAGE - Recombinant Human SCDGFB/PDGF-D protein (denatured) (AB134520)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SCDGFB/PDGF-D protein (denatured) (AB134520)

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

All lanes:

SDS-PAGE - Recombinant Human SCDGFB/PDGF-D protein (denatured) (ab134520) at 3 µg

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Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9GZP0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as SCDGFB.
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR","proteinLength":"Fragment","predictedMolecularWeight":"16.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":370,"aminoAcidStart":250,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9GZP0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCDGFB also known as PDGF-D is a member of the platelet-derived growth factor family. It plays a critical role in cell proliferation and differentiation. The molecular mass of PDGF-D is approximately 47 kDa. PDGF-D is expressed in various tissues including the heart kidney and vascular endothelial cells reflecting its involvement in diverse physiological processes.
Biological function summary

This growth factor facilitates angiogenesis and tissue development. PDGF-D is secreted as a homodimer and becomes active following proteolytic cleavage. This activated form then binds to the PDGF receptor-beta which is a part of a large protein complex involved in signaling cascades. These interactions underline its significant contribution to cellular signaling and vascular development.

Pathways

The involvement of PDGF-D in the PI3K/Akt and MAPK pathways is evident. These pathways play significant roles in regulating cell growth and survival. PDGF-D interacts with related proteins like PI3K and Akt in these pathways orchestrating cellular responses necessary for growth and survival. It highlights the protein's importance in maintaining normal cellular function and response to external signals.

PDGF-D has implications in cardiovascular disease and cancer. Its overexpression can lead to abnormal cell growth contributing to atherosclerosis and tumorigenesis. PDGF-D is associated with VEGF in promoting angiogenesis and fibroblast growth which can exacerbate these conditions. Understanding these links can help in developing targeted therapies for these diseases.
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Specifications

Form

Liquid

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General info

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).

Sequence similarities

Belongs to the PDGF/VEGF growth factor family.

Post-translational modifications

Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.

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Product protocols

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Target data

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
See full target information PDGFD
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Complementary Products

Primary Antibodies

AB181845

Anti-SCDGFB/PDGF-D antibody [EPR7266(2)]

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Primary Antibodies

AB23914

Anti-PDGF B antibody

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDGF B antibody (AB23914)

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Primary Antibodies

AB206423

Anti-EGF antibody [EPR19899]

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Western blot - Anti-EGF antibody [EPR19899] (AB206423)

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Primary Antibodies

AB203911

Anti-PDGF AA antibody [EPR19924]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-PDGF AA antibody [EPR19924] (AB203911)

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