Recombinant Human SCEL protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SCEL also known as sciellin is a part of the protein family found in the cornified envelope of the skin. It weighs about 135 kDa and exists mostly in stratified squamous epithelia. You can find SCEL in tissues such as the epidermis esophagus and in other keratinizing epithelium. SCEL plays a role in the structural integrity and resilience of these tissues due to its position near the inner surface of the plasma membrane.

Biological function summary

SCEL contributes to the proper formation and maintenance of the epidermal barrier. It is a component of the cornified envelope a multiprotein structure critical for the skin's barrier function. The formation involves cross-linking with other proteins like involucrin and filaggrin through the action of enzymes such as transglutaminases. SCEL's presence supports the mechanical stability and protective role of keratinized tissues.

Pathways

SCEL fits into the keratinization process which is important for protective barrier formation in skin. SCEL plays a part in the assembly of the cornified envelope interacting alongside involucrin loricrin and small proline-rich proteins. Another pathway involves the regulation of skin hydration through protein interactions in the epidermal differentiation complex. Proteins like filaggrin work closely with SCEL in these pathways to maintain skin integrity.

Associated diseases and disorders

Abnormal SCEL expression or function associates with skin conditions such as ichthyosis and psoriasis. These disorders often involve disrupted epidermal barrier function linking SCEL with other proteins involved in keratinocyte differentiation and cornification. For instance mutations or dysregulation in SCEL or its pathway components can lead to defective skin barrier and inflammatory skin disorders with possible involvement of proteins like filaggrin in the pathogenesis.