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AB99417

Recombinant Human SCGN/Secretagogin protein (His tag N-Terminus)

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Recombinant Human SCGN/Secretagogin protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 276 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

SECRET, SCGN, Secretagogin

2 Images
SDS-PAGE - Recombinant Human SCGN/Secretagogin protein (His tag N-Terminus) (AB99417)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SCGN/Secretagogin protein (His tag N-Terminus) (AB99417)

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

SDS-PAGE - Recombinant Human SCGN/Secretagogin protein (His tag N-Terminus) (AB99417)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SCGN/Secretagogin protein (His tag N-Terminus) (AB99417)

15% SDS-PAGE showing ab99417 at approximately 34.2kDa (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O76038

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

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Complementary Products

Proteins & Peptides

AB101214

Recombinant Human VAPB protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human VAPB protein (His tag N-Terminus) (AB101214)

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Primary Antibodies

AB137017

Anti-SCGN/Secretagogin antibody [EPR7477]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SCGN/Secretagogin antibody [EPR7477] (AB137017)

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  • 1
Proteins & Peptides

AB101108

Recombinant Human TNIP1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human TNIP1 protein (His tag N-Terminus) (AB101108)

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Proteins & Peptides

AB98233

Recombinant Human THTPA protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human THTPA protein (His tag N-Terminus) (AB98233)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as SCGN
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLHKVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDADSSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILALQENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP","proteinLength":"Full Length","predictedMolecularWeight":"34.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":276,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O76038","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCGN also known as Secretagogin is a calcium-binding protein with a molecular weight of approximately 33 kDa. It belongs to the family of EF-hand superfamily proteins which is known for its role in various cellular processes. Secretagogin predominantly expresses in neuroendocrine tissues such as the pancreas and central nervous system where it binds calcium and possibly modulates its signaling. It has drawn interest due to its distinctive expression pattern and potential role in regulated secretion.
Biological function summary

The role of Secretagogin extends beyond simple calcium binding. It participates in managing cytoskeleton dynamics through its ability to bind calcium impacting processes like vesicle trafficking. Although not part of a standard protein complex Secretagogin interacts with other cytoskeletal proteins and may influence the release of hormones. Its role in neurotransmission and insulin secretion showcases its significance in both the nervous and endocrine systems.

Pathways

Secretagogin interacts within signaling networks such as the calcium-signaling and insulin-secretion pathways. It has established relationships with other proteins like actin influencing cellular architecture and trafficking. Through these pathways Secretagogin appears instrumental in processes involving rapid response times such as neurotransmitter release or hormone secretion often acting in conjunction with or supporting other calcium-binding proteins.

Secretagogin has connections to diabetes and certain neuroendocrine tumors. Its involvement in insulin secretion makes it relevant in the context of diabetes where it might interact with malfunctioning insulin-related proteins. Additionally in neuroendocrine tumors altered Secretagogin expression could be linked with oncogenic processes as it shares pathways with proteins involved in cell-cycle regulation. Understanding these associations can aid in identifying potential therapeutic targets or biomarkers for these diseases.
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Specifications

Form

Liquid

Additional notes

ab99417 is purified using conventional chromatography techniques.

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General info

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Product protocols

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Target data

See full target information SCGN
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Product promise

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