Recombinant Human SCGN/Secretagogin protein is a Human Full Length protein, in the 1 to 276 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M D S S R E P T L G R L D A A G F W Q V W Q R F D A D E K G Y I E E K E L D A F F L H M L M K L G T D D T V M K A N L H K V K Q Q F M T T Q D A S K D G R I R M K E L A G M F L S E D E N F L L L F R R E N P L D S S V E F M Q I W R K Y D A D S S G F I S A A E L R N F L R D L F L H H K K A I S E A K L E E Y T G T M M K I F D R N K D G R L D L N D L A R I L A L Q E N F L L Q F K M D A C S T E E R K R D F E K I F A Y Y D V S K T G A L E G P E V D G F V K D M M E L V Q P S I S G V D L D K F R E I L L R H C D V N K D G K I Q K S E L A L C L G L K I N P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
SECRET, SCGN, Secretagogin
Recommended products
Recombinant Human SCGN/Secretagogin protein is a Human Full Length protein, in the 1 to 276 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- O76038-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M D S S R E P T L G R L D A A G F W Q V W Q R F D A D E K G Y I E E K E L D A F F L H M L M K L G T D D T V M K A N L H K V K Q Q F M T T Q D A S K D G R I R M K E L A G M F L S E D E N F L L L F R R E N P L D S S V E F M Q I W R K Y D A D S S G F I S A A E L R N F L R D L F L H H K K A I S E A K L E E Y T G T M M K I F D R N K D G R L D L N D L A R I L A L Q E N F L L Q F K M D A C S T E E R K R D F E K I F A Y Y D V S K T G A L E G P E V D G F V K D M M E L V Q P S I S G V D L D K F R E I L L R H C D V N K D G K I Q K S E L A L C L G L K I N P
- Accession
- O76038
- Protein length
- Full Length
- Predicted molecular weight
- 34.2 kDa
- Amino acids
- 1 to 276
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab99417 is purified using conventional chromatography techniques.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as SCGN
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SCGN also known as Secretagogin is a calcium-binding protein with a molecular weight of approximately 33 kDa. It belongs to the family of EF-hand superfamily proteins which is known for its role in various cellular processes. Secretagogin predominantly expresses in neuroendocrine tissues such as the pancreas and central nervous system where it binds calcium and possibly modulates its signaling. It has drawn interest due to its distinctive expression pattern and potential role in regulated secretion.
- Biological function summary
The role of Secretagogin extends beyond simple calcium binding. It participates in managing cytoskeleton dynamics through its ability to bind calcium impacting processes like vesicle trafficking. Although not part of a standard protein complex Secretagogin interacts with other cytoskeletal proteins and may influence the release of hormones. Its role in neurotransmission and insulin secretion showcases its significance in both the nervous and endocrine systems.
- Pathways
Secretagogin interacts within signaling networks such as the calcium-signaling and insulin-secretion pathways. It has established relationships with other proteins like actin influencing cellular architecture and trafficking. Through these pathways Secretagogin appears instrumental in processes involving rapid response times such as neurotransmitter release or hormone secretion often acting in conjunction with or supporting other calcium-binding proteins.
- Associated diseases and disorders
Secretagogin has connections to diabetes and certain neuroendocrine tumors. Its involvement in insulin secretion makes it relevant in the context of diabetes where it might interact with malfunctioning insulin-related proteins. Additionally in neuroendocrine tumors altered Secretagogin expression could be linked with oncogenic processes as it shares pathways with proteins involved in cell-cycle regulation. Understanding these associations can aid in identifying potential therapeutic targets or biomarkers for these diseases.
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1 product image
SDS-PAGE - Recombinant Human SCGN/Secretagogin protein (ab99417)
15% SDS-PAGE showing ab99417 at approximately 34.2kDa (3μg).
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