Recombinant Human SCLY protein is a Human Full Length protein, in the 1 to 445 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.
SCL, SCLY, Selenocysteine lyase, hSCL
Recombinant Human SCLY protein is a Human Full Length protein, in the 1 to 445 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
pH: 8
Constituents: 0.88% Sodium chloride, 0.32% Tris HCl
Purity is greater than 95% as determined by reducing SDS-PAGE. ab152026 is 0.2 µM filtered.
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Selenium binding protein 1 often referred to as SCLY participates in the metabolism of selenium an essential trace element in humans. It catalyzes the conversion of selenocysteine to alanine releasing elemental selenium in the process. SCLY has a molecular mass of approximately 62 kDa and is mostly expressed in the liver and kidney tissues indicating its role in metabolic processes in these organs. The activity of SCLY is significant in regulating selenium levels in cells which plays a broader part in protecting cells from oxidative stress.
The enzyme converts the selenium-containing amino acid selenocysteine which can impact the synthesis of selenoproteins that contain selenium and have various roles including antioxidant functions. SCLY does not work as part of a larger complex but it acts closely with other enzymes involved in selenium metabolism to maintain selenium homeostasis. Maintaining proper selenium balance is important for the antioxidant system in cells which prevents damage caused by oxidative stress.
Selenium metabolism involves SCLY as an important enzyme facilitating selenium reuse and selenoprotein synthesis. The metabolic pathway SCLY participates in interacts with the selenoprotein synthesis pathway where other key enzymes such as selenophosphate synthetase 1 are involved. The conversion of dietary selenium compounds to biologically active forms that cells can use relies on this pathway having proper function.
SCLY has links with disorders involving dysregulation of selenium metabolism such as selenium deficiency-related myopathy and liver disorders. Incorrect function of SCLY can impact the levels of selenoproteins connected to such diseases by oxidative damage and cell death. Selenoprotein P is one important protein that connects with SCLY-related impairments because reduced activity of SCLY might result in insufficient synthesis of this protein influential in distributing selenium throughout the body.
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