Recombinant Human SCLY protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The enzyme converts the selenium-containing amino acid selenocysteine which can impact the synthesis of selenoproteins that contain selenium and have various roles including antioxidant functions. SCLY does not work as part of a larger complex but it acts closely with other enzymes involved in selenium metabolism to maintain selenium homeostasis. Maintaining proper selenium balance is important for the antioxidant system in cells which prevents damage caused by oxidative stress.

Pathways

Selenium metabolism involves SCLY as an important enzyme facilitating selenium reuse and selenoprotein synthesis. The metabolic pathway SCLY participates in interacts with the selenoprotein synthesis pathway where other key enzymes such as selenophosphate synthetase 1 are involved. The conversion of dietary selenium compounds to biologically active forms that cells can use relies on this pathway having proper function.