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AB114727

Recombinant Human SCN2A protein (GST tag N-Terminus)

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Recombinant Human SCN2A protein (GST tag N-Terminus) is a Human Fragment protein, in the 273 to 362 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

HBA, NAC2, SCN2A1, SCN2A2, SCN2A, Sodium channel protein type 2 subunit alpha, HBSC II, Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.2

1 Images
SDS-PAGE - Recombinant Human SCN2A protein (GST tag N-Terminus) (AB114727)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SCN2A protein (GST tag N-Terminus) (AB114727)

12.5% SDS-PAGE Stained with Coomassie Blue

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, WB, ELISA

applications

Biologically active

No

Accession

Q99250

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Complementary Products

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-pan SCN antibody [EPR25134-4] (AB300112)

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Proteins & Peptides

AB114393

Recombinant Human TRA2B/SFRS10 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human TRA2B/SFRS10 protein (GST tag N-Terminus) (AB114393)

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Proteins & Peptides

AB156351

Recombinant Human Ephrin A3 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Ephrin A3 protein (denatured) (His tag N-Terminus) (AB156351)

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Proteins & Peptides

AB101155

Recombinant Human PHAP1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human PHAP1 protein (His tag N-Terminus) (AB101155)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Recombinant protein</p>" } } }
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Sequence info

[{"sequence":"NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNY","proteinLength":"Fragment","predictedMolecularWeight":"35.53 kDa","actualMolecularWeight":null,"aminoAcidEnd":362,"aminoAcidStart":273,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q99250","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SCN2A gene encodes for the Nav1.2 protein a voltage-gated sodium channel alpha subunit with a molecular weight of approximately 260 kDa. This protein acts mechanically by allowing sodium ions to flow into neurons upon depolarization making it fundamental for transmitting electrical signals. Nav1.2 is mainly expressed in the central nervous system especially in the brain regions involved in cognitive functions. Besides Nav1.2 SCI 2A is a popular alternate name for this protein.
Biological function summary

The Nav1.2 channel contributes to the generation and propagation of action potentials in neurons. It is part of a larger sodium channel complex that regulates neuronal excitability and synaptic transmission. This channel plays an essential role in maintaining the electrical activity that supports processes like learning and memory. Proper function of Nav1.2 ensures precise neuronal communication which is necessary for normal cognitive and neurological activities.

Pathways

The Nav1.2 channel integrates into the action potential pathway where it participates in the initiation and transmission of nerve impulses. It also intersects with synaptic transmission pathways working alongside proteins like Nav1.1 and Nav1.6 to ensure proper synaptic function. These interactions facilitate an effective communication system necessary for maintaining neural network stability.

Altered Nav1.2 function associates with epilepsy particularly early-onset epileptic encephalopathies. The gene mutations can disrupt normal sodium channel activity leading to increased neuronal excitability and seizure susceptibility. Furthermore variants in SCN2A link to autism spectrum disorders implicating sodium channel deficiencies in abnormal neurodevelopment. The protein interacts with auxiliary proteins like Navβ1 which influences the severity and presentation of these conditions.
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Specifications

Form

Liquid

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General info

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed : 1325650, PubMed : 17021166, PubMed : 28256214, PubMed : 29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity).

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily.

Post-translational modifications

May be ubiquitinated by NEDD4L; which would promote its endocytosis.. Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.. Sumoylated at Lys-38. Sumoylation is induced by hypoxia, increases voltage-gated sodium current and mediates the early response to acute hypoxia in neurons. Sumoylated SCN2A is located at the cell membrane.

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Product protocols

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Target data

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed : 1325650, PubMed : 17021166, PubMed : 28256214, PubMed : 29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity).
See full target information SCN2A
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Product promise

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