Recombinant Human SCN3B protein (His tag)
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Recombinant Human SCN3B protein (His tag) is a Human Fragment protein, in the 23 to 159 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
KIAA1158, SCN3B, Sodium channel regulatory subunit beta-3
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human SCN3B protein (His tag) (AB222957)
15% SDS-PAGE analysis of 3 μg ab222957.
MWt 18-28 kDa (SDS-PAGE under reducing conditions) .
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SCN3B influences the electrical excitability of neuronal and cardiac cells by serving as an auxiliary subunit of the voltage-gated sodium channels complex. It plays a supportive role by affecting the trafficking and functional integration of the alpha subunits which are key components for channel functionality. Through its involvement with these complexes SCN3B contributes to maintaining the balance and modulation of sodium ion flow across cell membranes which is critical for proper excitability in both neurons and myocytes.
Pathways
SCN3B's function integrates into pathways regulating electrical signaling in nerve and muscle tissues. Notably it participates in the cardiac action potential pathway ensuring that the rapid depolarization necessary for cardiac muscle contraction occurs effectively. It is also involved in the neuronal action potential signaling working closely with other proteins such as SCN1A and SCN5A which are alpha subunits of the sodium channels. These pathways highlight SCN3B's role in facilitating accurate and timely propagation of action potentials.
Specifications
Form
Liquid
Additional notes
Affinity purified
General info
Function
Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed : 20558140, PubMed : 21051419). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode (By similarity). Modulates the activity of SCN5A/Nav1.5 (PubMed : 20558140, PubMed : 21051419, PubMed : 24567321, PubMed : 31950564). Could also regulate the atypical sodium channel SCN7A/Nav2.1 (PubMed : 35301303). Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation (PubMed : 14975698).
Sequence similarities
Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
Post-translational modifications
Intramolecular disulfide bonds favor the voltage-gated sodium channel oligomeric complex assembly.. N-glycosylated.
Target data
Complementary Products
Product promise
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