Recombinant Human SCO1 protein is a Human Fragment protein, in the 132 to 300 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
>95% SDS-PAGE
< 1 EU/µg
Escherichia coli
GST tag N-Terminus
SDS-PAGE
No
G S P E F H M G K P L L G G P F S L T T H T G E R K T D K D Y L G Q W L L I Y F G F T H C P D V C P E E L E K M I Q V V D E I D S I T T L P D L T P L F I S I D P E R D T K E A I A N Y V K E F S P K L V G L T G T R E E V D Q V A R A Y R V Y Y S P G P K D E D E D Y I V D H T I I M Y L I G P D G E F L D Y F G Q N K R K G E I A A S I A T H M R P Y R K K S
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).
SCOD1, SCOD1, SCO1
Recombinant Human SCO1 protein is a Human Fragment protein, in the 132 to 300 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
>95% SDS-PAGE
< 1 EU/µg
Escherichia coli
GST tag N-Terminus
SDS-PAGE
No
No
Human
Reconstitute in PBS, pH 7.4
pH: 7.2
Constituents: 99% Phosphate Buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
G S P E F H M G K P L L G G P F S L T T H T G E R K T D K D Y L G Q W L L I Y F G F T H C P D V C P E E L E K M I Q V V D E I D S I T T L P D L T P L F I S I D P E R D T K E A I A N Y V K E F S P K L V G L T G T R E E V D Q V A R A Y R V Y Y S P G P K D E D E D Y I V D H T I I M Y L I G P D G E F L D Y F G Q N K R K G E I A A S I A T H M R P Y R K K S
Fragment
19.2 kDa
132 to 300
Recombinant
GST tag N-Terminus
Lyophilized
Greater than 95% as determined by reducing SDS-PAGE.
Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).
Belongs to the SCO1/2 family.
Mitochondrion, Mitochondrion inner membrane
Blue Ice
A few weeks
-20°C
-20°C
This supplementary information is collated from multiple sources and compiled automatically.
'SCO1' also known as SCO1 homolog is a protein involved in the assembly of cytochrome c oxidase the last enzyme in the mitochondrial respiratory chain. SCO1 has a mass of approximately 33 kDa and is commonly expressed in tissues with high energy demands such as muscle and brain tissue. The protein plays a mechanical role in copper delivery to cytochrome c oxidase subunits.
SCO1 participates in the transfer of copper ions essential for the catalytic activity of cytochrome c oxidase. It is a component of the cytochrome c oxidase assembly complex. This function ensures that the enzyme maintains its activity which is necessary for efficient cellular respiration. SCO1 interacts with other mitochondrial proteins responsible for stabilizing complex formation and securing enzyme functionality.
SCO1 contributes to the oxidative phosphorylation pathway and is important for the proper functioning of the mitochondrial electron transport chain. Its role in copper ion transfer is vital for energy production in cells. SCO1 interacts with the protein SCO2 another homolog involved in copper binding and transport to cytochrome c oxidase highlighting their interconnected tasks within this pathway.
Defects in SCO1 are linked to mitochondrial disorders specifically linked to cytochrome c oxidase deficiency and Leigh syndrome. These conditions involve disruptions in energy metabolism and present with severe clinical manifestations. Mutations in SCO1 can influence its interaction with other proteins such as COX17 essential for copper metabolism exacerbating the mitochondrial dysfunction in affected individuals.
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