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AB151389

Recombinant Human SCO1 protein

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Recombinant Human SCO1 protein is a Human Fragment protein, in the 132 to 300 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

SCOD1, SCO1, Cytochrome c oxidase assembly factor SCO1

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O75880

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS, pH 7.4

Storage buffer

pH: 7.2 Constituents: 99% Phosphate Buffer, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Complementary Products

Primary Antibodies

AB181975

Anti-S100 alpha 6/PRA antibody [EPR13084-69]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S100 alpha 6/PRA antibody [EPR13084-69] (AB181975)

  • 5
  • 1
Primary Antibodies

AB195045

Anti-PAX6 antibody [EPR15858]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAX6 antibody [EPR15858] (AB195045)

  • 5
  • 9
Primary Antibodies

AB137869

Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (AB137869)

  • 5
  • 9
Primary Antibodies

AB57602

Anti-Mitofusin 2 + Mitofusin 1 antibody [3C9]

BOND RX™ Validated

Western blot - Anti-Mitofusin 2 + Mitofusin 1 antibody [3C9] (AB57602)

  • 4
  • 14
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GSPEFHMGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKKS","proteinLength":"Fragment","predictedMolecularWeight":"19.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":300,"aminoAcidStart":132,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75880","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
A few weeks
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

'SCO1' also known as SCO1 homolog is a protein involved in the assembly of cytochrome c oxidase the last enzyme in the mitochondrial respiratory chain. SCO1 has a mass of approximately 33 kDa and is commonly expressed in tissues with high energy demands such as muscle and brain tissue. The protein plays a mechanical role in copper delivery to cytochrome c oxidase subunits.
Biological function summary

SCO1 participates in the transfer of copper ions essential for the catalytic activity of cytochrome c oxidase. It is a component of the cytochrome c oxidase assembly complex. This function ensures that the enzyme maintains its activity which is necessary for efficient cellular respiration. SCO1 interacts with other mitochondrial proteins responsible for stabilizing complex formation and securing enzyme functionality.

Pathways

SCO1 contributes to the oxidative phosphorylation pathway and is important for the proper functioning of the mitochondrial electron transport chain. Its role in copper ion transfer is vital for energy production in cells. SCO1 interacts with the protein SCO2 another homolog involved in copper binding and transport to cytochrome c oxidase highlighting their interconnected tasks within this pathway.

Defects in SCO1 are linked to mitochondrial disorders specifically linked to cytochrome c oxidase deficiency and Leigh syndrome. These conditions involve disruptions in energy metabolism and present with severe clinical manifestations. Mutations in SCO1 can influence its interaction with other proteins such as COX17 essential for copper metabolism exacerbating the mitochondrial dysfunction in affected individuals.
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Specifications

Form

Lyophilized

Additional notes

Greater than 95% as determined by reducing SDS-PAGE.

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General info

Function

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Together with SCO2, involved in delivering copper to the Cu(A) site on MT-CO2/COX2 (PubMed : 15229189, PubMed : 15659396, PubMed : 16735468, PubMed : 17189203, PubMed : 19336478). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).

Sequence similarities

Belongs to the SCO1/2 family.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Together with SCO2, involved in delivering copper to the Cu(A) site on MT-CO2/COX2 (PubMed : 15229189, PubMed : 15659396, PubMed : 16735468, PubMed : 17189203, PubMed : 19336478). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).
See full target information SCO1
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