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AB202238

Recombinant Human SCO1 protein

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Recombinant Human SCO1 protein is a Human Fragment protein, in the 132 to 301 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

SCOD1, SCO1

1 Images
SDS-PAGE - Recombinant Human SCO1 protein (AB202238)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SCO1 protein (AB202238)

15% SDS-PAGE analysis of ab202238 (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag C-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O75880

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 89% PBS, 10% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKKSLEHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"20.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":301,"aminoAcidStart":132,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75880","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

'SCO1' also known as SCO1 homolog is a protein involved in the assembly of cytochrome c oxidase the last enzyme in the mitochondrial respiratory chain. SCO1 has a mass of approximately 33 kDa and is commonly expressed in tissues with high energy demands such as muscle and brain tissue. The protein plays a mechanical role in copper delivery to cytochrome c oxidase subunits.
Biological function summary

SCO1 participates in the transfer of copper ions essential for the catalytic activity of cytochrome c oxidase. It is a component of the cytochrome c oxidase assembly complex. This function ensures that the enzyme maintains its activity which is necessary for efficient cellular respiration. SCO1 interacts with other mitochondrial proteins responsible for stabilizing complex formation and securing enzyme functionality.

Pathways

SCO1 contributes to the oxidative phosphorylation pathway and is important for the proper functioning of the mitochondrial electron transport chain. Its role in copper ion transfer is vital for energy production in cells. SCO1 interacts with the protein SCO2 another homolog involved in copper binding and transport to cytochrome c oxidase highlighting their interconnected tasks within this pathway.

Defects in SCO1 are linked to mitochondrial disorders specifically linked to cytochrome c oxidase deficiency and Leigh syndrome. These conditions involve disruptions in energy metabolism and present with severe clinical manifestations. Mutations in SCO1 can influence its interaction with other proteins such as COX17 essential for copper metabolism exacerbating the mitochondrial dysfunction in affected individuals.
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Specifications

Form

Liquid

Additional notes

Purified using conventional chromatography techniques.

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General info

Function

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed : 15229189, PubMed : 15659396, PubMed : 16735468, PubMed : 17189203, PubMed : 19336478). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).

Sequence similarities

Belongs to the SCO1/2 family.

Subcellular localisation

Mitochondrion

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed : 15229189, PubMed : 15659396, PubMed : 16735468, PubMed : 17189203, PubMed : 19336478). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).
See full target information SCO1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Proteins & Peptides

AB151389

Recombinant Human SCO1 protein

proteins-peptides

recombinant-human-sco1-protein-ab151389

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