Recombinant Human SCRG1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCRG1 also known as Stimulator of Chondrogenesis 1 is a protein weighing approximately 11 kDa. It is primarily expressed in the brain with notable presence in other tissues such as the liver and kidney. SCRG1 has a notable role in developmental processes due to its ability to interact with cell surface molecules. This protein is involved in signaling pathways that mediate cell communication and proliferation.

Biological function summary

SCRG1 contributes to various cellular functions especially within the central nervous system. It participates in the modulation of neuronal survival and connectivity. SCRG1 does not form part of a large multi-protein complex but it interacts closely with several other signaling molecules involved in neurodevelopment and tissue maintenance. Its activity impacts cell morphology and tissue integrity.

Pathways

SCRG1 operates within several key biological pathways including the Notch signaling pathway and growth factor-mediated pathways. It associates with proteins such as Jagged1 and Delta-like ligands which are components of the Notch pathway. These interactions enable SCRG1 to influence cellular differentiation and tissue patterning emphasizing its role in developmental processes.

SCRG1 has links to neurodegenerative diseases and certain cancers. Its dysregulation associates with Alzheimer's disease where it may impact amyloid-beta aggregation interacting with proteins like APP (amyloid precursor protein). Furthermore aberrant expression of SCRG1 can contribute to oncogenesis particularly in hepatocellular carcinoma interacting with key growth regulators such as TGF-beta. These relationships suggest SCRG1's potential as a biomarker or therapeutic target in these conditions.