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AB202177

Recombinant Human SCRN1 protein (His tag N-Terminus)

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Recombinant Human SCRN1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 414 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

KIAA0193, SCRN1, Secernin-1

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SDS-PAGE - Recombinant Human SCRN1 protein (His tag N-Terminus) (AB202177)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SCRN1 protein (His tag N-Terminus) (AB202177)

15% SDS-PAGE analysis of ab202177 (3 μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q12765

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISIDQVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERGETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKVTEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLDCGAGKDSLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDPSRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIESDQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK","proteinLength":"Full Length","predictedMolecularWeight":"48.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":414,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q12765","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCRN1 also known as Secernin-1 is a protein involved in endosomal trafficking and lysosomal degradation. It has a molecular mass of approximately 45 kDa. SCRN1 is widely expressed in various tissues including the brain liver and lungs suggesting its involvement in numerous cellular processes. It is known to regulate the fusion of endosomes with lysosomes ensuring the proper degradation of internalized materials.
Biological function summary

SCRN1 acts as a regulatory component facilitating vesicle-mediated transport and protein degradation. This ensures cellular homeostasis and response to extracellular stimuli. Although SCRN1 is not a part of a larger complex it demonstrates interaction with endosomal components affecting cellular protein turnover rates. Recent studies highlight its role in cellular signaling contributing to the adaptation of cells to changing environmental conditions.

Pathways

SCRN1 plays an impactful role in the endocytic and lysosomal pathways. It interacts with Rab7 an important protein in these pathways which ensures efficient lysosomal function and autophagy processes. Through its action in these pathways SCRN1 influences cellular recycle of nutrients and elimination of cellular debris contributing to cellular maintenance and turnover.

SCRN1 has been linked to neurological conditions and cancer. Dysfunctional SCRN1 activity associates with neurodegenerative diseases like Alzheimer's where the protein's impact on lysosomal degradation is disrupted. Also SCRN1 connects with proteins like amyloid precursor protein (APP) adding to the understanding of its role in these diseases. In cancer SCRN1 dysregulation may affect tumor proliferation and metastasis especially through its interactions with oncogene-related pathways.
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Specifications

Form

Liquid

Additional notes

ab202177 was purified using conventional chromatography techniques.

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General info

Function

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).

Sequence similarities

Belongs to the peptidase C69 family. Secernin subfamily.

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Product protocols

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Target data

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).
See full target information SCRN1
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