Recombinant Human SCRN1 protein is a Human Full Length protein, in the 1 to 414 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M A A A P P S Y C F V A F P P R A K D G L V V F G K N S A R P R D E V Q E V V Y F S A A D H E P E S K V E C T Y I S I D Q V P R T Y A I M I S R P A W L W G A E M G A N E H G V C I A N E A I N T R E P A A E I E A L L G M D L V R L G L E R G E T A K E A L D V I V S L L E E H G Q G G N Y F E D A N S C H S F Q S A Y L I V D R D E A W V L E T I G K Y W A A E K V T E G V R C I C S Q L S L T T K M D A E H P E L R S Y A Q S Q G W W T G E G E F N F S E V F S P V E D H L D C G A G K D S L E K Q E E S I T V Q T M M N T L R D K A S G V C I D S E F F L T T A S G V S V L P Q N R S S P C I H Y F T G T P D P S R S I F K P F I F V D D V K L V P K T Q S P C F G D D D P A K K E P R F Q E K P D R R H E L Y K A H E W A R A I I E S D Q E Q G R K L R S T M L E L E K Q G L E A M E E I L T S S E P L D P A E V G D L F Y D C V D T E I K F F K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).
Alternative names
KIAA0193, SCRN1, Secernin-1
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Recombinant Human SCRN1 protein is a Human Full Length protein, in the 1 to 414 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q12765-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 89% PBS, 10% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M A A A P P S Y C F V A F P P R A K D G L V V F G K N S A R P R D E V Q E V V Y F S A A D H E P E S K V E C T Y I S I D Q V P R T Y A I M I S R P A W L W G A E M G A N E H G V C I A N E A I N T R E P A A E I E A L L G M D L V R L G L E R G E T A K E A L D V I V S L L E E H G Q G G N Y F E D A N S C H S F Q S A Y L I V D R D E A W V L E T I G K Y W A A E K V T E G V R C I C S Q L S L T T K M D A E H P E L R S Y A Q S Q G W W T G E G E F N F S E V F S P V E D H L D C G A G K D S L E K Q E E S I T V Q T M M N T L R D K A S G V C I D S E F F L T T A S G V S V L P Q N R S S P C I H Y F T G T P D P S R S I F K P F I F V D D V K L V P K T Q S P C F G D D D P A K K E P R F Q E K P D R R H E L Y K A H E W A R A I I E S D Q E Q G R K L R S T M L E L E K Q G L E A M E E I L T S S E P L D P A E V G D L F Y D C V D T E I K F F K
- Accession
- Q12765
- Protein length
- Full Length
- Predicted molecular weight
- 48.8 kDa
- Amino acids
- 1 to 414
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab202177 was purified using conventional chromatography techniques.
General info
- Function
Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).
- Sequence similarities
Belongs to the peptidase C69 family. Secernin subfamily.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SCRN1 also known as Secernin-1 is a protein involved in endosomal trafficking and lysosomal degradation. It has a molecular mass of approximately 45 kDa. SCRN1 is widely expressed in various tissues including the brain liver and lungs suggesting its involvement in numerous cellular processes. It is known to regulate the fusion of endosomes with lysosomes ensuring the proper degradation of internalized materials.
- Biological function summary
SCRN1 acts as a regulatory component facilitating vesicle-mediated transport and protein degradation. This ensures cellular homeostasis and response to extracellular stimuli. Although SCRN1 is not a part of a larger complex it demonstrates interaction with endosomal components affecting cellular protein turnover rates. Recent studies highlight its role in cellular signaling contributing to the adaptation of cells to changing environmental conditions.
- Pathways
SCRN1 plays an impactful role in the endocytic and lysosomal pathways. It interacts with Rab7 an important protein in these pathways which ensures efficient lysosomal function and autophagy processes. Through its action in these pathways SCRN1 influences cellular recycle of nutrients and elimination of cellular debris contributing to cellular maintenance and turnover.
- Associated diseases and disorders
SCRN1 has been linked to neurological conditions and cancer. Dysfunctional SCRN1 activity associates with neurodegenerative diseases like Alzheimer's where the protein's impact on lysosomal degradation is disrupted. Also SCRN1 connects with proteins like amyloid precursor protein (APP) adding to the understanding of its role in these diseases. In cancer SCRN1 dysregulation may affect tumor proliferation and metastasis especially through its interactions with oncogene-related pathways.
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1 product image
SDS-PAGE - Recombinant Human SCRN1 protein (ab202177)
15% SDS-PAGE analysis of ab202177 (3 μg).
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