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AB204157

Recombinant Human SCYL2 protein

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Recombinant Human SCYL2 protein is a Human Fragment protein, in the 1 to 520 aa range, expressed in Baculovirus infected Sf9 cells, with >85%, suitable for SDS-PAGE.

View Alternative Names

CVAK104, KIAA1360, SCYL2, SCY1-like protein 2, Coated vesicle-associated kinase of 104 kDa

1 Images
SDS-PAGE - Recombinant Human SCYL2 protein (AB204157)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SCYL2 protein (AB204157)

SDS-PAGE analysis of ab204157 which was determined to be >85% pure by densitometry.

Key facts

Purity

>85% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6P3W7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Complementary Products

Cell Lines & Lysates

AB264926

Human SCYL2 knockout HeLa cell line

Sanger Sequencing - Human SCYL2 knockout HeLa cell line (AB264926)

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Cell Lines & Lysates

AB259100

Human SCYL2 knockout HeLa cell lysate

Sanger Sequencing - Human SCYL2 knockout HeLa cell lysate (AB259100)

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Primary Antibodies

AB221195

Anti-SCYL2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SCYL2 antibody (AB221195)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYVKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLD","proteinLength":"Fragment","predictedMolecularWeight":"84 kDa","actualMolecularWeight":null,"aminoAcidEnd":520,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q6P3W7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCYL2 also known by the name SCY1-like 2 is a member of the SCY1-like family of proteins. It has a mass of approximately 110 kDa. SCYL2 is an accessory protein with kinase-like activity but lacks enzymatic function. The protein localizes mainly in the trans-Golgi network and the cytoplasm. It is expressed in various tissues including brain and heart indicating its potential roles in different organs and systems within the body.
Biological function summary

The human SCYL2 protein is involved in cellular trafficking and is part of the coatomer complex which assists in vesicle formation and transport. It helps in clathrin-mediated endocytosis which is important for internalizing molecules like lipids and proteins. SCYL2 interacts with other proteins such as clathrin heavy chain and auxilin demonstrating its role in maintaining cellular homoeostasis and membrane dynamics.

Pathways

SCYL2 participates in the endocytosis and intracellular transport processes. It plays a part in the AP-2 complex pathway which is essential for the vesicle docking and cargo selection. Additionally SCYL2 associates with huntingtin an important protein involved in cellular interactions vital for neuron function and integrity connecting its role to neurological processes.

SCYL2 shows associations with neurological conditions like Huntington's disease. Disruptions in its regulatory functions can affect protein transport and neuron stability potentially leading to neurodegenerative symptoms. SCYL2 also interacts with tau proteins which are relevant in Alzheimer's disease indicating its potential influence in tauopathy-related neuronal deterioration.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed : 15809293, PubMed : 16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily.

Post-translational modifications

Could autophosphorylate in presence of poly-L-lysine.

Subcellular localisation

Endosome membrane

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Product protocols

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Target data

Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed : 15809293, PubMed : 16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity).
See full target information SCYL2
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